دورية أكاديمية
Anti-tumor activities of a novel chlorin derivative for photodynamic therapy in vitro and in vivo
| العنوان: | Anti-tumor activities of a novel chlorin derivative for photodynamic therapy in vitro and in vivo |
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| المؤلفون: | Li-Jun Zhang, Lai-Xing Wang, Wei-Li Zhang, Yi-Jia Yan, Zhi-Long Chen |
| المصدر: | Journal of Innovative Optical Health Sciences, Vol 8, Iss 1, Pp 1540003-1-1540003-11 (2015) |
| بيانات النشر: | World Scientific Publishing, 2015. |
| سنة النشر: | 2015 |
| المجموعة: | LCC:Technology LCC:Optics. Light |
| مصطلحات موضوعية: | TPMC, chlorin, tumor, photosensitizer, photodynamic therapy, Technology, Optics. Light, QC350-467 |
| الوصف: | In this study, a novel photosensitizer meso-tetra (3-pyrrolidinomethyl-4-methoxyphenyl) chlorin (TPMC) was reported. It displays a characteristic long wavelength absorption peak at 656 nm and it shows a singlet oxygen quantum yield of 0.48. After light irradiation with 650 nm laser, it can kill Eca-109 and SMMC-7721 cells in vitro (25 mW/cm2, 1.2 to 3.6 J/cm2) and destroy Eca-109 tumor in nude mice (50 mW/cm2, 90 J/cm2). It has the perspective to be developed as a new anti-tumor drug in photodynamic therapy (PDT) photodiagnosis, and deserves further investigation. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1793-5458 1793-7205 17935458 |
| Relation: | https://doaj.org/toc/1793-5458; https://doaj.org/toc/1793-7205 |
| DOI: | 10.1142/S1793545815400039 |
| URL الوصول: | https://doaj.org/article/10edcfe263f14a99986a2f6b1a08bb85 |
| رقم الأكسشن: | edsdoj.10edcfe263f14a99986a2f6b1a08bb85 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17935458 17937205 |
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| DOI: | 10.1142/S1793545815400039 |