دورية أكاديمية
A Deg-protease family protein in marine Synechococcus is involved in outer membrane protein organization
| العنوان: | A Deg-protease family protein in marine Synechococcus is involved in outer membrane protein organization |
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| المؤلفون: | Rhona Kayra Stuart, Bianca eBrahamsha, Brian ePalenik |
| المصدر: | Frontiers in Marine Science, Vol 1 (2014) |
| بيانات النشر: | Frontiers Media S.A., 2014. |
| سنة النشر: | 2014 |
| المجموعة: | LCC:Science LCC:General. Including nature conservation, geographical distribution |
| مصطلحات موضوعية: | copper tolerance, Marine Synechococcus, Deg protease, envelope stress, phosphate stress, Science, General. Including nature conservation, geographical distribution, QH1-199.5 |
| الوصف: | Deg-family proteases are a periplasm-associated group of proteins that are known to be involved in envelope stress responses and are found in most microorganisms. Orthologous genes SYNW2176 (in strain WH8102) and sync_2523 (strain CC9311) are predicted members of the Deg-protease family and are among the few genes induced by copper stress in both open ocean and coastal marine Synechococcus strains. In contrast to the lack of a phenotype in a similar knockout in Synechocystis PCC6803, a SYNW2176 knockout mutant in strain WH8102 was much more resistant to copper than the wild-type. The mutant also exhibited a significantly altered outer membrane protein composition which may contribute to copper resistance, longer lag phase after transfer, low-level consistent alkaline phosphatase activity, and an inability to induce high alkaline phosphatase activity in response to phosphate stress. This phenotype suggests a protein-quality-control role for SYNW2176, the absence of which leads to a constitutively activated stress response. Deg-protease family proteins in this ecologically important cyanobacterial group thus help to determine outer membrane responses to both nutrients and toxins. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2296-7745 |
| Relation: | http://journal.frontiersin.org/Journal/10.3389/fmars.2014.00016/full; https://doaj.org/toc/2296-7745 |
| DOI: | 10.3389/fmars.2014.00016 |
| URL الوصول: | https://doaj.org/article/10ee7386b90a4d95bce7434aee5be243 |
| رقم الأكسشن: | edsdoj.10ee7386b90a4d95bce7434aee5be243 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22967745 |
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| DOI: | 10.3389/fmars.2014.00016 |