Organ-on-a-Chip, or OOC, is a widely discussed topic in science due to its many unique advantages in the biomedical field. Nevertheless, there is still much to learn about OOC's various aspects of conception and its significance for the advancement of medical technology in the future. A platform for organs-on-a-chip must go through the fabrication process. Various manufacturing processes were also used depending on the required disease modelling and drug screening. Organs on a chip technology included the Brain-On-Chip, Kidney-On-Chip, Liver-On-Chip, and Heart-On-Chip. In order to provide new beginnings with a thorough understanding of OOC, we have studied the most recent developments in organ-on-a-chip expertise and critically assessed its relevant features in this research.