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أعرض في EDS

Mir-421 in plasma as a potential diagnostic biomarker for precancerous gastric lesions and early gastric cancer

التفاصيل البيبلوغرافية
العنوان: Mir-421 in plasma as a potential diagnostic biomarker for precancerous gastric lesions and early gastric cancer
المؤلفون: Jianlin Chen, Lihua Wu, Yifan Sun, Qi Yin, Xianhua Chen, Siqun Liang, Qingyan Meng, Haihua Long, Fangying Li, Changjun Luo, Xiaorong Xiao
المصدر: PeerJ, Vol 7, p e7002 (2019)
بيانات النشر: PeerJ Inc., 2019.
سنة النشر: 2019
المجموعة: LCC:Medicine
LCC:Biology (General)
مصطلحات موضوعية: Early diagnosis, Precancerous lesions, MicroRNA-421, Gastric cancer, Medicine, Biology (General), QH301-705.5
الوصف: Objective MicroRNA (miR)-421 plays a key role in cancer progression. It has been reported that circulating miR-421may be a potential tumor marker for the diagnosis of several cancers. However, the role of miR-421 in plasma as a potential biomarker in the diagnosis of precancerous gastric lesions (Pre) and early-stage gastric cancer (GC) remains poorly understood. In this study, we investigated miR-421 in plasma as a novel potential biomarker for the detection of precancerous gastric lesions and early-stage (GC). Materials & Methods The miRNA content was determined by quantitative real-time polymerase chain reaction (qRT-PCR). MiR-421 content in all subjects was normalized by endogenous miRNA (miR-16). The diagnostic value of miR-421 for Pre and GC was assessed by comparing receiver operating characteristic (ROC) analysis with traditional tumor markers, including CEA, CA125, CA153, CA211 and CA50. The correlation between the expression of miR-421 and the pathological characteristics of Pre and GC was analyzed. Results Elevated expression of miR-421 in plasma can robustly distinguish the normal population from Pre and GC cases, especially in the early stages of gastric cancer cases (all p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2167-8359
Relation: https://peerj.com/articles/7002.pdf; https://peerj.com/articles/7002/; https://doaj.org/toc/2167-8359
DOI: 10.7717/peerj.7002
URL الوصول: https://doaj.org/article/111ac51f3b9e46288e5cfe5d40eec21f
رقم الأكسشن: edsdoj.111ac51f3b9e46288e5cfe5d40eec21f
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:21678359
DOI:10.7717/peerj.7002