Outcomes After Accelerated Partial Breast Irradiation in Women With Triple Negative Subtype and Other 'High Risk' Variables Categorized as Cautionary in The ASTRO Guidelines
التفاصيل البيبلوغرافية
العنوان:
Outcomes After Accelerated Partial Breast Irradiation in Women With Triple Negative Subtype and Other 'High Risk' Variables Categorized as Cautionary in The ASTRO Guidelines
PurposeTo report a primary objective clinical outcome of ipsilateral breast recurrence following accelerated partial breast irradiation (APBI) in women with triple negative and other high risk breast cancer (as described in 2017 ASTRO guidelines) (i.e., age 40–49, size 2.1–3.0 cm, estrogen receptor negative and invasive lobular breast cancer). Secondary objectives of axillary and regional failure as well as overall survival are also reported.Methods and MaterialPatients from two clinical trials (NCT01185145, NCT01185132) were treated with 38.5 Gy IMRT or 3D-CRT APBI w/3.85 Gy fraction/BID fractionation for 10 fractions. Triple negative and other high risk patients (n=269) were compared to a total of 478 low risk patients which ASTRO defined as “suitable” for APBI. High risk patients, for the purpose of this study, were defined as those who possess one or more high risk criteria: triple negative (n=30), tumor size >2 cm
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