دورية أكاديمية
Longitudinal immune kinetics of COVID-19 booster versus primary series vaccination: Insight into the annual vaccination strategy
| العنوان: | Longitudinal immune kinetics of COVID-19 booster versus primary series vaccination: Insight into the annual vaccination strategy |
|---|---|
| المؤلفون: | Min Joo Choi, Hakjun Hyun, Jung Yeon Heo, Yu Bin Seo, Ji Yun Noh, Hee Jin Cheong, Woo Joo Kim, Hwa Jung Kim, Ju-yeon Choi, Young Jae Lee, Eun Joo Chung, Su-Hwan Kim, Hyeonji Jeong, Byoungguk Kim, Joon Young Song |
| المصدر: | Heliyon, Vol 10, Iss 5, Pp e27211- (2024) |
| بيانات النشر: | Elsevier, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Science (General) LCC:Social sciences (General) |
| مصطلحات موضوعية: | SARS-CoV-2, COVID-19 vaccines, Longevity, Immunogenicity, Booster shot, Science (General), Q1-390, Social sciences (General), H1-99 |
| الوصف: | Background: Data on the durability of booster dose immunity of COVID-19 vaccines are relatively limited. Methods: Immunogenicity was evaluated for up to 9–12 months after the third dose of vaccination in 94 healthy adults. Results: Following the third dose, the anti-spike immunoglobulin G (IgG) antibody response against the wild-type was boosted markedly, which decreased gradually over time. However, even 9–12 months after the booster dose, both the median and geometric mean of anti-spike IgG antibody levels were higher than those measured 4 weeks after the second dose. Breakthrough infection during the Omicron-dominant period boosted neutralizing antibody titers against Omicron sublineages (BA.1 and BA.5) and the ancestral strain. T-cell immune response was efficiently induced and maintained during the study period. Conclusions: mRNA vaccine booster dose elicited durable humoral immunity for up to 1 year after the third dose and T-cell immunity was sustained during the study period, supporting an annual COVID-19 vaccination strategy. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2405-8440 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2405844024032420; https://doaj.org/toc/2405-8440 |
| DOI: | 10.1016/j.heliyon.2024.e27211 |
| URL الوصول: | https://doaj.org/article/114d9d388109460a9c8113b9b1cea2c9 |
| رقم الأكسشن: | edsdoj.114d9d388109460a9c8113b9b1cea2c9 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24058440 |
|---|---|
| DOI: | 10.1016/j.heliyon.2024.e27211 |