دورية أكاديمية
Immune response in SARS-CoV-2 infection: the role of interferons type I and type III
العنوان: | Immune response in SARS-CoV-2 infection: the role of interferons type I and type III |
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المؤلفون: | Caciane Portela Sousa, Carlos Brites |
المصدر: | Brazilian Journal of Infectious Diseases, Vol 24, Iss 5, Pp 428-433 (2020) |
بيانات النشر: | Elsevier, 2020. |
سنة النشر: | 2020 |
المجموعة: | LCC:Infectious and parasitic diseases LCC:Microbiology |
مصطلحات موضوعية: | IFN type I, IFN type III, SARS-CoV-2, Immune response, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502 |
الوصف: | Background: There is scarce information on the human immune response to the SARS-CoV-2 infection, and on the exacerbated inflammatory reaction observed in severe COVID-19 cases. Objective: To review the available evidence on the role of interferons type I and type III to SARS-CoV-2 infection. Methods: We reviewed the available published evidence on the role of immune response to SARS-CoV-2 infection as well as recent publications on characteristics and outcomes of COVID-19, and their relationship with interferons type I and type III. Results: The available data indicates that immune response plays an important role in controlling SARS-CoV-2 infection and the immune dysregulation can significantly modify the clinical outcomes of affected patients. In addition, the evidence suggests that IFN type I and III can play an important role in controlling viremia and modulating the immune response in COVID-19. Conclusions: Due to their central role in immune response against SARS-CoV-2 infection, IFN type I and III could be considered for treatment of COVID-19. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1413-8670 |
Relation: | http://www.sciencedirect.com/science/article/pii/S1413867020301100; https://doaj.org/toc/1413-8670 |
DOI: | 10.1016/j.bjid.2020.07.011 |
URL الوصول: | https://doaj.org/article/117ffd1623d9469796d03a7b1c662369 |
رقم الأكسشن: | edsdoj.117ffd1623d9469796d03a7b1c662369 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 14138670 |
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DOI: | 10.1016/j.bjid.2020.07.011 |