دورية أكاديمية
أعرض في EDS

Immune response in SARS-CoV-2 infection: the role of interferons type I and type III

التفاصيل البيبلوغرافية
العنوان: Immune response in SARS-CoV-2 infection: the role of interferons type I and type III
المؤلفون: Caciane Portela Sousa, Carlos Brites
المصدر: Brazilian Journal of Infectious Diseases, Vol 24, Iss 5, Pp 428-433 (2020)
بيانات النشر: Elsevier, 2020.
سنة النشر: 2020
المجموعة: LCC:Infectious and parasitic diseases
LCC:Microbiology
مصطلحات موضوعية: IFN type I, IFN type III, SARS-CoV-2, Immune response, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502
الوصف: Background: There is scarce information on the human immune response to the SARS-CoV-2 infection, and on the exacerbated inflammatory reaction observed in severe COVID-19 cases. Objective: To review the available evidence on the role of interferons type I and type III to SARS-CoV-2 infection. Methods: We reviewed the available published evidence on the role of immune response to SARS-CoV-2 infection as well as recent publications on characteristics and outcomes of COVID-19, and their relationship with interferons type I and type III. Results: The available data indicates that immune response plays an important role in controlling SARS-CoV-2 infection and the immune dysregulation can significantly modify the clinical outcomes of affected patients. In addition, the evidence suggests that IFN type I and III can play an important role in controlling viremia and modulating the immune response in COVID-19. Conclusions: Due to their central role in immune response against SARS-CoV-2 infection, IFN type I and III could be considered for treatment of COVID-19.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1413-8670
Relation: http://www.sciencedirect.com/science/article/pii/S1413867020301100; https://doaj.org/toc/1413-8670
DOI: 10.1016/j.bjid.2020.07.011
URL الوصول: https://doaj.org/article/117ffd1623d9469796d03a7b1c662369
رقم الأكسشن: edsdoj.117ffd1623d9469796d03a7b1c662369
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14138670
DOI:10.1016/j.bjid.2020.07.011