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A Genome-Wide Association Study of Attention Function in a Population-Based Sample of Children.

التفاصيل البيبلوغرافية
العنوان: A Genome-Wide Association Study of Attention Function in a Population-Based Sample of Children.
المؤلفون: Silvia Alemany, Natàlia Vilor-Tejedor, Mariona Bustamante, Jesús Pujol, Dídac Macià, Gerard Martínez-Vilavella, Raquel Fenoll, Mar Alvárez-Pedrerol, Joan Forns, Jordi Júlvez, Elisabet Suades-González, Sabrina Llop, Marisa Rebagliato, Jordi Sunyer
المصدر: PLoS ONE, Vol 11, Iss 9, p e0163048 (2016)
بيانات النشر: Public Library of Science (PLoS), 2016.
سنة النشر: 2016
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Attention function filters and selects behaviorally relevant information. This capacity is impaired in some psychiatric disorders and has been proposed as an endophenotype for Attention-Deficit/Hyperactivity Disorder; however, its genetic basis remains largely unknown. This study aimed to identify single nucleotide polymorphism (SNPs) associated with attention function.The discovery sample included 1655 children (7-12 years) and the replication sample included 546 children (5-8 years). Five attention outcomes were assessed using the computerized Attentional Network Test (ANT): alerting, orienting, executive attention, Hit Reaction time (HRT) and the standard error of HRT (HRTSE). A Genome-wide Association Study was conducted for each outcome. Gene set enrichment analyses were performed to detect biological pathways associated with attention outcomes. Additional neuroimaging analyses were conducted to test neural effects of detected SNPs of interest.Thirteen loci showed suggestive evidence of association with attention function (P
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC5033492?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0163048
URL الوصول: https://doaj.org/article/11bc77f0511b42cf931d03355ffff230
رقم الأكسشن: edsdoj.11bc77f0511b42cf931d03355ffff230
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0163048