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Discovery of tanshinone derivatives with anti-MRSA activity via targeted bio-transformation

التفاصيل البيبلوغرافية
العنوان: Discovery of tanshinone derivatives with anti-MRSA activity via targeted bio-transformation
المؤلفون: Wenni He, Miaomiao Liu, Pei Huang, Wael M. Abdel-Mageed, Jianying Han, Jeramie D. Watrous, Don D. Nguyen, Wenzhao Wang, Fuhang Song, Huanqin Dai, Jingyu Zhang, Ronald J. Quinn, Tanja Grkovi, Houwei Luo, Lixin Zhang, Xueting Liu
المصدر: Synthetic and Systems Biotechnology, Vol 1, Iss 3, Pp 187-194 (2016)
بيانات النشر: KeAi Communications Co., Ltd., 2016.
سنة النشر: 2016
المجموعة: LCC:Biotechnology
LCC:Biology (General)
مصطلحات موضوعية: Biotransformation, Glycosylation, Tanshinone IIA, Mucor rouxianus, Biotechnology, TP248.13-248.65, Biology (General), QH301-705.5
الوصف: Two potent anti-MRSA tanshinone glycosides (1 and 2) were discovered by targeted microbial biotransformation, along with rapid identification via MS/MS networking. Serial reactions including dehydrogenation, demethylations, reduction, glycosylation and methylation have been observed after incubation of tanshinone IIA and fungus Mucor rouxianus AS 3.3447. In addition, tanshinosides B (2) showed potent activities against serial clinical isolates of oxacillin-resistant Staphylococcus aureus with MIC values of 0.78 μg/mL. This is the first study that shows a significant increase in the level and activities of tanshinone glycosides relative to the substrate tanshinone IIA.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2405-805X
Relation: http://www.sciencedirect.com/science/article/pii/S2405805X15300223; https://doaj.org/toc/2405-805X
DOI: 10.1016/j.synbio.2016.05.002
URL الوصول: https://doaj.org/article/a11c33e1c62f44d1a13ee71538c484f2
رقم الأكسشن: edsdoj.11c33e1c62f44d1a13ee71538c484f2
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:2405805X
DOI:10.1016/j.synbio.2016.05.002