دورية أكاديمية
New Insights into the Reparative Angiogenesis after Myocardial Infarction
| العنوان: | New Insights into the Reparative Angiogenesis after Myocardial Infarction |
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| المؤلفون: | Marta Martín-Bórnez, Débora Falcón, Rosario Morrugares, Geraldine Siegfried, Abdel-Majid Khatib, Juan A. Rosado, Isabel Galeano-Otero, Tarik Smani |
| المصدر: | International Journal of Molecular Sciences, Vol 24, Iss 15, p 12298 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | angiogenesis, endothelial cell, cardiac repair, heart infarction, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Myocardial infarction (MI) causes massive loss of cardiac myocytes and injury to the coronary microcirculation, overwhelming the limited capacity of cardiac regeneration. Cardiac repair after MI is finely organized by complex series of procedures involving a robust angiogenic response that begins in the peri-infarcted border area of the infarcted heart, concluding with fibroblast proliferation and scar formation. Efficient neovascularization after MI limits hypertrophied myocytes and scar extent by the reduction in collagen deposition and sustains the improvement in cardiac function. Compelling evidence from animal models and classical in vitro angiogenic approaches demonstrate that a plethora of well-orchestrated signaling pathways involving Notch, Wnt, PI3K, and the modulation of intracellular Ca2+ concentration through ion channels, regulate angiogenesis from existing endothelial cells (ECs) and endothelial progenitor cells (EPCs) in the infarcted heart. Moreover, cardiac repair after MI involves cell-to-cell communication by paracrine/autocrine signals, mainly through the delivery of extracellular vesicles hosting pro-angiogenic proteins and non-coding RNAs, as microRNAs (miRNAs). This review highlights some general insights into signaling pathways activated under MI, focusing on the role of Ca2+ influx, Notch activated pathway, and miRNAs in EC activation and angiogenesis after MI. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/24/15/12298; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms241512298 |
| URL الوصول: | https://doaj.org/article/11df6a17a053462399600344d9e11f1f |
| رقم الأكسشن: | edsdoj.11df6a17a053462399600344d9e11f1f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms241512298 |