دورية أكاديمية
A influência da piperina na biodisponibilidade de fármacos: uma abordagem molecular
| العنوان: | A influência da piperina na biodisponibilidade de fármacos: uma abordagem molecular |
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| المؤلفون: | Ramon G. de Oliveira, Edilson B. Alencar - Filho, Mário L. A. A. Vasconcellos |
| المصدر: | Química Nova, Vol 37, Iss 1, Pp 69-73 (2014) |
| بيانات النشر: | Sociedade Brasileira de Química, 2014. |
| سنة النشر: | 2014 |
| المجموعة: | LCC:Chemistry |
| مصطلحات موضوعية: | piperine, enzymatic inhibition, molecular docking, Chemistry, QD1-999 |
| الوصف: | Piperine is the major alkaloid of Piper nigrum Linn., used as a spice and in folk medicine. We present a molecular docking study supporting experimental data on the enhancement in bioavailability of propranolol, theophylline, phenytoin, nevirapine, nimesulide, pyrazinamide, carbamazepine, and spartein in the presence of piperine. The complex formed with piperine and CYP3A4 was shown to be the most stable of all, with a binding energy of -8.60 kcal/mol. This explains the related mechanism of drug-herb interaction, since the better anchoring of piperine in the active site of CYP3A4 can hinder the drug-enzyme interaction, thereby increasing the bioavailability of the drugs studied. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Spanish; Castilian Portuguese |
| تدمد: | 1678-7064 0100-4042 |
| Relation: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422014000100013&lng=en&tlng=en; https://doaj.org/toc/1678-7064 |
| DOI: | 10.1590/S0100-40422014000100013 |
| URL الوصول: | https://doaj.org/article/e122f38c121f4fafaee76798eff22fdd |
| رقم الأكسشن: | edsdoj.122f38c121f4fafaee76798eff22fdd |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16787064 01004042 |
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| DOI: | 10.1590/S0100-40422014000100013 |