دورية أكاديمية
أعرض في EDS

Recurrence of a t(8;21)-Positive Acute Myeloid Leukemia in the Form of a Granulocytic Sarcoma Involving Cranial Bones: A Diagnostic and Therapeutic Challenge

التفاصيل البيبلوغرافية
العنوان: Recurrence of a t(8;21)-Positive Acute Myeloid Leukemia in the Form of a Granulocytic Sarcoma Involving Cranial Bones: A Diagnostic and Therapeutic Challenge
المؤلفون: Ambra Di Veroli, Alessandro Micarelli, Mariagiovanna Cefalo, Eleonora Ceresoli, Daniela Nasso, Laura Cicconi, Simone Mauramati, Fabrizio Ottaviani, Adriano Venditti, Sergio Amadori
المصدر: Case Reports in Hematology, Vol 2013 (2013)
بيانات النشر: Wiley, 2013.
سنة النشر: 2013
المجموعة: LCC:Diseases of the blood and blood-forming organs
مصطلحات موضوعية: Diseases of the blood and blood-forming organs, RC633-647.5
الوصف: Granulocytic sarcoma (GS) is a rare extramedullary solid tumor defined as an accumulation of myeloblasts or immature myeloid cells. It can cooccur with or precede the acute myeloid leukemia (AML) as well as following treated AML. The incidence of GS in AML patients is 3–8% but it significantly rises in M2 FAB subtype AML. This variety of AML harbors t(8;21) in up to 20–25% of cases (especially in children and black ones of African origin) and, at a molecular level, it is characterized by the generation of a fusion gene known as RUNX1-RUNX1T1. Approximately 10% of M2 AML patients will develop GS, as a consequence, the t(8;21) and the relative transcript represent the most common cytogenetic and molecular abnormalities in GS. FLT3-ITD mutation was rarely described in AML patients presenting with GS. FLT3 ITD is generally strongly associated with poor prognosis in AML, and is rarely reported in patients with t(8;21). GS presentation is extremely variable depending on organs involved; in general, cranial bones and sinus are very rarely affected sites. We report a rare case of GS occurring as a recurrence of a previously treated t(8;21), FLT3-ITD positive AML, involving mastoid bones and paravertebral tissues.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2090-6560
2090-6579
Relation: https://doaj.org/toc/2090-6560; https://doaj.org/toc/2090-6579
DOI: 10.1155/2013/245395
URL الوصول: https://doaj.org/article/1249c1cfe6f340f6b92ca6f01ba5f2f8
رقم الأكسشن: edsdoj.1249c1cfe6f340f6b92ca6f01ba5f2f8
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20906560
20906579
DOI:10.1155/2013/245395