دورية أكاديمية
hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets
| العنوان: | hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets |
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| المؤلفون: | Qiong Zhang, Wei Liu, Hong-Mei Zhang, Gui-Yan Xie, Ya-Ru Miao, Mengxuan Xia, An-Yuan Guo |
| المصدر: | Genomics, Proteomics & Bioinformatics, Vol 18, Iss 2, Pp 120-128 (2020) |
| بيانات النشر: | Oxford University Press, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Biology (General) LCC:Computer applications to medicine. Medical informatics |
| مصطلحات موضوعية: | Transcription factor, ChIP-seq, Transcriptional regulation, Human, Database, Biology (General), QH301-705.5, Computer applications to medicine. Medical informatics, R858-859.7 |
| الوصف: | Transcription factors (TFs) as key regulators play crucial roles in biological processes. The identification of TF–target regulatory relationships is a key step for revealing functions of TFs and their regulations on gene expression. The accumulated data of chromatin immunoprecipitation sequencing (ChIP-seq) provide great opportunities to discover the TF–target regulations across different conditions. In this study, we constructed a database named hTFtarget, which integrated huge human TF target resources (7190 ChIP-seq samples of 659 TFs and high-confidence binding sites of 699 TFs) and epigenetic modification information to predict accurate TF–target regulations. hTFtarget offers the following functions for users to explore TF–target regulations: (1) browse or search general targets of a query TF across datasets; (2) browse TF–target regulations for a query TF in a specific dataset or tissue; (3) search potential TFs for a given target gene or non-coding RNA; (4) investigate co-association between TFs in cell lines; (5) explore potential co-regulations for given target genes or TFs; (6) predict candidate TF binding sites on given DNA sequences; (7) visualize ChIP-seq peaks for different TFs and conditions in a genome browser. hTFtarget provides a comprehensive, reliable and user-friendly resource for exploring human TF–target regulations, which will be very useful for a wide range of users in the TF and gene expression regulation community. hTFtarget is available at http://bioinfo.life.hust.edu.cn/hTFtarget. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1672-0229 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S1672022920300954; https://doaj.org/toc/1672-0229 |
| DOI: | 10.1016/j.gpb.2019.09.006 |
| URL الوصول: | https://doaj.org/article/a12aa05604ce41759bbcbcfdb9dd1ef1 |
| رقم الأكسشن: | edsdoj.12aa05604ce41759bbcbcfdb9dd1ef1 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16720229 |
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| DOI: | 10.1016/j.gpb.2019.09.006 |