التفاصيل البيبلوغرافية
العنوان:
TGF-β activation by bone marrow-derived thrombospondin-1 causes Schistosoma- and hypoxia-induced pulmonary hypertension
المؤلفون:
Rahul Kumar , Claudia Mickael , Biruk Kassa , Liya Gebreab , Jeffrey C. Robinson , Daniel E. Koyanagi , Linda Sanders , Lea Barthel , Christina Meadows , Daniel Fox , David Irwin , Min Li , B. Alexandre McKeon , Suzette Riddle , R. Dale Brown , Leslie E. Morgan , Christopher M. Evans , Daniel Hernandez-Saavedra , Angela Bandeira , James P. Maloney , Todd M. Bull , William J. Janssen , Kurt R. Stenmark , Rubin M. Tuder , Brian B. Graham
المصدر:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
بيانات النشر:
Nature Portfolio, 2017.
سنة النشر:
2017
المجموعة:
LCC:Science
مصطلحات موضوعية:
Science
الوصف:
Thrombospondin-1 (TSP-1) activates latent TGF-β in the extracellular matrix. Here the authors show that inappropriate activation of latent TGF-β in murine, bovine and human lung by monocyte-produced TSP-1 causes pulmonary hypertension, and that interference with the activation process prevents disease development.
نوع الوثيقة:
article
وصف الملف:
electronic resource
اللغة:
English
تدمد:
2041-1723
Relation:
https://doaj.org/toc/2041-1723
DOI:
10.1038/ncomms15494
URL الوصول:
https://doaj.org/article/12cae9f76300462c9772bdd1e67bd44a
رقم الأكسشن:
edsdoj.12cae9f76300462c9772bdd1e67bd44a
قاعدة البيانات:
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