دورية أكاديمية
Hematotoxicity and nephrotoxicity of long-term administration of Guiera senegalensis (J.F. Gme), Cassia occidentalis (Linn), and Ziziphus mauritiana (Lam) leaves obtained in Birnin Kebbi, Nigeria
| العنوان: | Hematotoxicity and nephrotoxicity of long-term administration of Guiera senegalensis (J.F. Gme), Cassia occidentalis (Linn), and Ziziphus mauritiana (Lam) leaves obtained in Birnin Kebbi, Nigeria |
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| المؤلفون: | Tajudeen O. Yahaya, Esther O. Oladele, MDA Bunza, Abdulrahman B. Yusuf, Abdulrazak Izuafa, Jamilu B. Danjuma, Kelechi Nnochiri |
| المصدر: | Journal of HerbMed Pharmacology, Vol 11, Iss 3, Pp 367-374 (2022) |
| بيانات النشر: | Shahrekord University of Medical Sciences, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine (General) LCC:Therapeutics. Pharmacology |
| مصطلحات موضوعية: | anemia, hemoglobin, inflammation, lead, phytochemicals, heavy metal poisonous, toxicity, Medicine (General), R5-920, Therapeutics. Pharmacology, RM1-950 |
| الوصف: | Introduction: Previously, we established the phytochemical composition and short-term administration safety of Guiera senegalensis (sabara), Cassia occidentalis (coffee senna), and Ziziphus mauritiana (jujube) leaves, which are common medicinal plants in Northern Nigeria. In the current study, heavy metal contents and long-term administration effects of the plants’ leaf extracts on hematological parameters and the kidneys of albino rats (Rattus norvegicus) were investigated. The heavy metals analyzed were copper, lead, cadmium, nickel, and manganese, while the hematological parameters evaluated were packed cell volume, hemoglobin, red blood cells, white blood cells, lymphocytes, and monocytes. Methods: Twenty-four mixed-sex rats were distributed into four groups of six rats each. Group 1 was made the control, while groups 2, 3, and 4 were administered 1000 mg kg-1 one of the plants extracts for 90 days. Blood and kidney samples were collected across the groups for hematological and histopathological examinations. Results: The heavy metals were present in the extracts within the World Health Organization’s acceptable limits. The treated rats were anemic compared to the control. However, on average, only the C. occidentalis group showed significant differences (P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2345-5004 |
| Relation: | http://herbmedpharmacol.com/PDF/jhp-11-367.pdf; https://doaj.org/toc/2345-5004 |
| DOI: | 10.34172/jhp.2022.42 |
| URL الوصول: | https://doaj.org/article/12cd4e07f4c34d39b5820976d11f9bf7 |
| رقم الأكسشن: | edsdoj.12cd4e07f4c34d39b5820976d11f9bf7 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23455004 |
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| DOI: | 10.34172/jhp.2022.42 |