دورية أكاديمية
PA200-Mediated Proteasomal Protein Degradation and Regulation of Cellular Senescence
| العنوان: | PA200-Mediated Proteasomal Protein Degradation and Regulation of Cellular Senescence |
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| المؤلفون: | Pei Wen, Yan Sun, Tian-Xia Jiang, Xiao-Bo Qiu |
| المصدر: | International Journal of Molecular Sciences, Vol 25, Iss 11, p 5637 (2024) |
| بيانات النشر: | MDPI AG, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | proteasome, protein degradation, PA200, Blm10, PSME4, aging, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Cellular senescence is closely related to DNA damage, proteasome inactivity, histone loss, epigenetic alterations, and tumorigenesis. The mammalian proteasome activator PA200 (also referred to as PSME4) or its yeast ortholog Blm10 promotes the acetylation-dependent degradation of the core histones during transcription, DNA repair, and spermatogenesis. According to recent studies, PA200 plays an important role in senescence, probably because of its role in promoting the degradation of the core histones. Loss of PA200 or Blm10 is a major cause of the decrease in proteasome activity during senescence. In this paper, recent research progress on the association of PA200 with cellular senescence is summarized, and the potential of PA200 to serve as a therapeutic target in age-related diseases is discussed. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/25/11/5637; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms25115637 |
| URL الوصول: | https://doaj.org/article/12e606584ea9428291ebcda3895ece12 |
| رقم الأكسشن: | edsdoj.12e606584ea9428291ebcda3895ece12 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms25115637 |