دورية أكاديمية
Impact of surgical resection extension on outcome for primary well-differentiated thyroid cancer—a retrospective analysis
| العنوان: | Impact of surgical resection extension on outcome for primary well-differentiated thyroid cancer—a retrospective analysis |
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| المؤلفون: | S. Muller, M. Senne, A. Kirschniak, A. Königsrainer, R. Bares, C. Falch |
| المصدر: | World Journal of Surgical Oncology, Vol 15, Iss 1, Pp 1-5 (2017) |
| بيانات النشر: | BMC, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Surgery LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | Well-differentiated thyroid cancer, Lymph node dissection, Completion surgery, Thyroidectomy, Surgery, RD1-811, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Abstract Background The surgical resection extension in well-differentiated thyroid cancer is controversially discussed with the possibility of an overtreatment on the one hand against the risk of local disease recurrence. The aim of this study is to evaluate how the surgical resection extension with the adjunction of radioiodine therapy affects postoperative morbidity and the oncologic outcome of patients primarily treated for well-differentiated thyroid cancer. Methods All patients undergoing primary surgery for a well-differentiated, non-recurrent thyroid cancer from January 2005 to April 2013 at Tuebingen University Hospital were retrospectively analyzed. Results Papillary thyroid cancer (PTC) was present in 73 patients (including 27 papillary microcarinoma) and follicular thyroid cancer in 14 patients. Fifty-six of 87 patients (64%) underwent one-stage surgery, of which 26 patients (30%) received simultaneous lymph node dissection (LND). The remaining 31 patients (36%) underwent a two-stage completion surgery (29 patients with LND). Only in three patients a single lymph node metastasis was newly detected during two-stage completion surgery. Patients with LND at either one-stage and two-stage completion surgery had a significant higher rate of transient postoperative hypocalcemia. Postoperative adjuvant radioiodine therapy was performed in 68 of 87 patients (78%). After a median follow-up of 69 months [range 9–104], one local recurrence was documented in a patient suffering from PTC 23 months after surgery. Conclusion No prophylactic two-stage lymphadenectomy should be performed in case of well-differentiated thyroid cancer to avoid unnecessary complication without any proven oncologic benefit. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1477-7819 |
| Relation: | http://link.springer.com/article/10.1186/s12957-017-1261-x; https://doaj.org/toc/1477-7819 |
| DOI: | 10.1186/s12957-017-1261-x |
| URL الوصول: | https://doaj.org/article/12f9c8eaa3bf4c90a3de745ba3e2a9a1 |
| رقم الأكسشن: | edsdoj.12f9c8eaa3bf4c90a3de745ba3e2a9a1 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 14777819 |
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| DOI: | 10.1186/s12957-017-1261-x |