ObjectiveWe investigated the temporal trends and examined age-, period-, and cohort-specific effects of injury-related deaths among residents in Jiangsu to provide evidence for future injury prevention.MethodsThis study included 406,936 injury deaths from the Jiangsu provincial population death registration system. The average annual percent change (AAPC) in age-standardized mortality rates (ASMRs) was analyzed using joinpoint regression. Age-period-cohort models were generated to explore the effects of age, period, and birth cohort effects on mortality risk.ResultsASMRs for all injuries (AAPC = −2.3%), road traffic accidents (AAPC = −5.3%), suicide (AAPC = −3.8%), and drowning (AAPC = −3.9%) showed a downward trend during 2012–2021(all p