دورية أكاديمية
Hypergravity enhances the therapeutic effect of dexamethasone in allergic asthma and rhinitis animal model.
| العنوان: | Hypergravity enhances the therapeutic effect of dexamethasone in allergic asthma and rhinitis animal model. |
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| المؤلفون: | Tae Young Jang, Ah-Yeoun Jung, Soonjo Kwon, Young Hyo Kim |
| المصدر: | PLoS ONE, Vol 13, Iss 5, p e0197594 (2018) |
| بيانات النشر: | Public Library of Science (PLoS), 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | We investigated whether the therapeutic effects of dexamethasone for allergic asthma and rhinitis were enhanced in mice when exposed to hypergravity. Forty mice were divided into 5 groups (n = 8/group): Control group received saline intraperitoneally (i.p.) and intranasally (i.n.); Asthma group received i.p./i.n. ovalbumin (OVA) for inducing allergic asthma/rhinitis; Dexa group received i.n. dexamethasone (0.75 mg/kg) 30 minutes before each OVA challenge; Hypergravity group was subjected to allergic asthma/rhinitis as well as exposed to 5 G hypergravity for 30 days; Finally in Dexa/Hypergravity group, hypergravity and dexamethasone were used simultaneously during induction of allergic asthma/rhinitis. Dexa group and Hypergravity group showed a significant decrease in serum total IgE levels compared to the Asthma group (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1932-6203 |
| Relation: | http://europepmc.org/articles/PMC5957331?pdf=render; https://doaj.org/toc/1932-6203 |
| DOI: | 10.1371/journal.pone.0197594 |
| URL الوصول: | https://doaj.org/article/1309e3d2d6704ca6957489d0920db03d |
| رقم الأكسشن: | edsdoj.1309e3d2d6704ca6957489d0920db03d |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0197594 |