دورية أكاديمية
أعرض في EDS

Clinicopathological features and outcomes of adrenocortical carcinoma: A single institution experience

التفاصيل البيبلوغرافية
العنوان: Clinicopathological features and outcomes of adrenocortical carcinoma: A single institution experience
المؤلفون: Lekha Madhavan Nair, K M Jagathnath Krishna, Aswin Kumar, Susan Mathews, John Joseph, Francis Vadakkumparambil James
المصدر: Indian Journal of Urology, Vol 35, Iss 3, Pp 213-217 (2019)
بيانات النشر: Wolters Kluwer Medknow Publications, 2019.
سنة النشر: 2019
المجموعة: LCC:Diseases of the genitourinary system. Urology
مصطلحات موضوعية: Diseases of the genitourinary system. Urology, RC870-923
الوصف: Introduction: Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with aggressive behavior. Most of our knowledge about this rare tumor is based on retrospective case series. This study aimed at analyzing the clinicopathological features and outcomes of patients treated at a tertiary cancer center in India. Patients and Methods: We retrospectively reviewed the data of patients with ACC registered from January 2006 to December 2015. Results: Thirty-seven patients were included in the study, 20 males and 17 females. Median age was 49 (18–78) years. Hormonal overproduction was noticed in 27% of patients. Median tumor size was 10 cm (2–22). Seventeen patients had metastatic disease and 20 patients were localised at diagnosis. Median follow-up was 22 months and median overall survival (OS) was 23.46 months. OS at 2 years and 5 years was 46.1% and 21%, respectively. The median disease-free survival (DFS) was 20 months. DFS at 2 years and 5 years was 45% and 24%, respectively. Age, sex, tumor size, hormonal overproduction, tumor laterality, and stage of the disease did not influence survival. However, advanced stage was associated with higher risk for recurrence. (P = 0.03). Conclusion: ACC is a rare endocrine malignancy with very poor survival rates. Rate of recurrence is high even after complete surgery. Systemic treatment options are limited. Newer agents are needed to improve outcome.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 0970-1591
1998-3824
Relation: http://www.indianjurol.com/article.asp?issn=0970-1591;year=2019;volume=35;issue=3;spage=213;epage=217;aulast=Nair; https://doaj.org/toc/0970-1591; https://doaj.org/toc/1998-3824
DOI: 10.4103/iju.IJU_19_19
URL الوصول: https://doaj.org/article/130b74df44404213a9255cf30a01d5cc
رقم الأكسشن: edsdoj.130b74df44404213a9255cf30a01d5cc
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:09701591
19983824
DOI:10.4103/iju.IJU_19_19