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SerpinB3 administration protects liver against ischemia-reperfusion injury

التفاصيل البيبلوغرافية
العنوان: SerpinB3 administration protects liver against ischemia-reperfusion injury
المؤلفون: Cristian Turato, Mariapia Vairetti, Marta Cagna, Alessandra Biasiolo, Andrea Ferrigno, Santina Quarta, Mariagrazia Ruvoletto, Silvia De Siervi, Patrizia Pontisso, Laura Giuseppina Di Pasqua
المصدر: European Journal of Histochemistry, Vol 66, Iss 4 (2022)
بيانات النشر: PAGEPress Publications, 2022.
سنة النشر: 2022
المجموعة: LCC:Biology (General)
مصطلحات موضوعية: Ischemia/reperfusion, SerpinB3, inflammation, Biology (General), QH301-705.5
الوصف: We have investigated the change in SerpinB3 during hepatic ischemia and the potential role of its antiprotease activity in cell protection by the administration of wild-type SerpinB3 (SerpinB3-WT) or active loop-deleted recombinant SerpinB3 protein (SerpinB3-D) in a rat model of ischemia (60 min)/reperfusion (60 min) (I/R). A time-dependent increase of SerpinB3, both at transcription and protein level, was found in ischemic livers after 60, 120 and 180 min. SerpinB3-WT decreased polymorphonuclear cell infiltration and serum enzymes and increased ATP when compared with I/R group. These events were not obtained using SerpinB3-D. No significant changes in both liver SerpinB3 mRNA and protein were found in all I/R groups considered. The present data show that the administration of SerpinB3-WT reduced the I/R injury and this effect appears to be dependent on its anti-protease activity.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1121-760X
2038-8306
Relation: https://www.ejh.it/index.php/ejh/article/view/3561; https://doaj.org/toc/1121-760X; https://doaj.org/toc/2038-8306
DOI: 10.4081/ejh.2022.3561
URL الوصول: https://doaj.org/article/132dd393be9445019719bfe2e49b6ede
رقم الأكسشن: edsdoj.132dd393be9445019719bfe2e49b6ede
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:1121760X
20388306
DOI:10.4081/ejh.2022.3561