دورية أكاديمية
A high-fructose diet induces changes in pp185 phosphorylation in muscle and liver of rats
| العنوان: | A high-fructose diet induces changes in pp185 phosphorylation in muscle and liver of rats |
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| المؤلفون: | M. Ueno, R.M.N. Bezerra, M.S. Silva, D.Q. Tavares, C.R. Carvalho, M.J.A. Saad |
| المصدر: | Brazilian Journal of Medical and Biological Research, Vol 33, Iss 12, Pp 1421-1427 (2000) |
| بيانات النشر: | Associação Brasileira de Divulgação Científica, 2000. |
| سنة النشر: | 2000 |
| المجموعة: | LCC:Medicine (General) LCC:Biology (General) |
| مصطلحات موضوعية: | fructose, insulin receptor, pp185 phosphorylation, Medicine (General), R5-920, Biology (General), QH301-705.5 |
| الوصف: | Insulin stimulates the tyrosine kinase activity of its receptor resulting in the tyrosine phosphorylation of pp185, which contains insulin receptor substrates IRS-1 and IRS-2. These early steps in insulin action are essential for the metabolic effects of insulin. Feeding animals a high-fructose diet results in insulin resistance. However, the exact molecular mechanism underlying this effect is unknown. In the present study, we determined the levels and phosphorylation status of the insulin receptor and pp185 (IRS-1/2) in liver and muscle of rats submitted to a high-fructose diet evaluated by immunoblotting with specific antibodies. Feeding fructose (28 days) induced a discrete insulin resistance, as demonstrated by the insulin tolerance test. Plasma glucose and serum insulin and cholesterol levels of the two groups of rats, fructose-fed and control, were similar, whereas plasma triacylglycerol concentration was significantly increased in the rats submitted to the fructose diet (P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0100-879X 1414-431X |
| Relation: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000001200004; https://doaj.org/toc/0100-879X; https://doaj.org/toc/1414-431X |
| DOI: | 10.1590/S0100-879X2000001200004 |
| URL الوصول: | https://doaj.org/article/134939ea85a44ab0b658758fb0efc2cb |
| رقم الأكسشن: | edsdoj.134939ea85a44ab0b658758fb0efc2cb |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 0100879X 1414431X |
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| DOI: | 10.1590/S0100-879X2000001200004 |