دورية أكاديمية
Baseline Plasma C-Reactive Protein Concentrations and Motor Prognosis in Parkinson Disease.
| العنوان: | Baseline Plasma C-Reactive Protein Concentrations and Motor Prognosis in Parkinson Disease. |
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| المؤلفون: | Atsushi Umemura, Tomoko Oeda, Kenji Yamamoto, Satoshi Tomita, Masayuki Kohsaka, Kwiyoung Park, Hiroshi Sugiyama, Hideyuki Sawada |
| المصدر: | PLoS ONE, Vol 10, Iss 8, p e0136722 (2015) |
| بيانات النشر: | Public Library of Science (PLoS), 2015. |
| سنة النشر: | 2015 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | C-reactive protein (CRP), a blood inflammatory biomarker, is associated with the development of Alzheimer disease. In animal models of Parkinson disease (PD), systemic inflammatory stimuli can promote neuroinflammation and accelerate dopaminergic neurodegeneration. However, the association between long-term systemic inflammations and neurodegeneration has not been assessed in PD patients.To investigate the longitudinal effects of baseline CRP concentrations on motor prognosis in PD.Retrospective analysis of 375 patients (mean age, 69.3 years; mean PD duration, 6.6 years). Plasma concentrations of high-sensitivity CRP were measured in the absence of infections, and the Unified Parkinson's Disease Rating Scale Part III (UPDRS-III) scores were measured at five follow-up intervals (Days 1-90, 91-270, 271-450, 451-630, and 631-900).Change of UPDRS-III scores from baseline to each of the five follow-up periods.Change in UPDRS-III scores was significantly greater in PD patients with CRP concentrations ≥0.7 mg/L than in those with CRP concentrations |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1932-6203 |
| Relation: | http://europepmc.org/articles/PMC4550234?pdf=render; https://doaj.org/toc/1932-6203 |
| DOI: | 10.1371/journal.pone.0136722 |
| URL الوصول: | https://doaj.org/article/1356b385d0784bfc98086f85f68cca9e |
| رقم الأكسشن: | edsdoj.1356b385d0784bfc98086f85f68cca9e |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0136722 |