دورية أكاديمية
A comprehensive review of the Direct Peptide Reactivity Assay in skin sensitization testing: Applicability, limitations, and considerations
| العنوان: | A comprehensive review of the Direct Peptide Reactivity Assay in skin sensitization testing: Applicability, limitations, and considerations |
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| المؤلفون: | Omeragić Elma, Imamović Belma, Dedić Mirza, Mujezin Indira, Bečić Ervina |
| المصدر: | Arhiv za farmaciju, Vol 74, Iss 2, Pp 118-132 (2024) |
| بيانات النشر: | Pharmaceutical Association of Serbia, Belgrade, Serbia, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Pharmacy and materia medica |
| مصطلحات موضوعية: | dpra, in chemico method, skin sensitization, Pharmacy and materia medica, RS1-441 |
| الوصف: | Skin sensitization is a crucial endpoint in the safety assessment of chemicals, with the Direct Peptide Reactivity Assay (DPRA) emerging as a valuable in chemico method for evaluating a substance's sensitization potential. This review delves into the principles, applicability, and limitations of the DPRA within the context of the Adverse Outcome Pathway (AOP) framework for skin sensitization. We examine the DPRA'srole in addressing the molecular initiating event of skin sensitization, its integration into Integrated Approaches to Testing and Assessment (IATA), and its performance in predicting sensitizers. The review also highlights the challenges in testing certain categories of chemicals and the importance of considering the DPRA's results alongside other complementary methods. By providing a comprehensive overview of the DPRA, this review aims to inform researchers, regulators, and clinicians about its utility and limitations in the context of skin sensitization testing. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Serbian |
| تدمد: | 0004-1963 2217-8767 |
| Relation: | https://scindeks-clanci.ceon.rs/data/pdf/0004-1963/2024/0004-19632402118O.pdf; https://doaj.org/toc/0004-1963; https://doaj.org/toc/2217-8767 |
| DOI: | 10.5937/arhfarm74-49552 |
| URL الوصول: | https://doaj.org/article/135a1eb001c547939ffe9709add8947b |
| رقم الأكسشن: | edsdoj.135a1eb001c547939ffe9709add8947b |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 00041963 22178767 |
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| DOI: | 10.5937/arhfarm74-49552 |