دورية أكاديمية
Recent advances in glucose oxidase-based nanocarriers for tumor targeting therapy
| العنوان: | Recent advances in glucose oxidase-based nanocarriers for tumor targeting therapy |
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| المؤلفون: | Su Li, Qinghua Wang, Zhen Jia, Mengting Da, Jiuda Zhao, Rui Yang, Daozhen Chen |
| المصدر: | Heliyon, Vol 9, Iss 10, Pp e20407- (2023) |
| بيانات النشر: | Elsevier, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Science (General) LCC:Social sciences (General) |
| مصطلحات موضوعية: | Glucose oxidase, Nanocarriers, Targeted therapy, Cancer, Science (General), Q1-390, Social sciences (General), H1-99 |
| الوصف: | Glucose oxidase (GOx) can specifically catalyze the conversion of β-d-glucose into gluconic acid and hydrogen peroxide (H2O2) in the presence of oxygen, making it promising for tumor starvation therapy and oxidative therapy. However, GOx's immunogenicity, poor in vivo stability, short half-life, and potential systemic toxicity, limit its application in cancer therapy. Nanocarriers are capable of improving the pharmacological properties of therapeutic drugs (e.g. stability, circulating half-life, and tumor accumulation) and lower toxicity, hence resolving GOx issues and enhancing its efficacy. Although the application of targeted nanocarriers based on GOx has recently flourished, this field has not yet been reviewed and evaluated. Herein, we initially examined the mechanism of GOx-based nanocarriers for enhanced tumor therapy. Also, we present a comprehensive and up-to-date review that highlights GOx-based nanocarriers for tumor targeting therapy. This review expands on GOx-based nano-targeted combination therapies from both passive and active targeting perspectives, meanwhile, active targeting is further classified into ligand-mediated targeting and physical-mediated targeting. Furthermore, this review also emphasizes the present challenges and promising advancements. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2405-8440 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2405844023076156; https://doaj.org/toc/2405-8440 |
| DOI: | 10.1016/j.heliyon.2023.e20407 |
| URL الوصول: | https://doaj.org/article/e136d6cb5d224fa384e072efc20d570d |
| رقم الأكسشن: | edsdoj.136d6cb5d224fa384e072efc20d570d |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24058440 |
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| DOI: | 10.1016/j.heliyon.2023.e20407 |