دورية أكاديمية
Advanced analysis and applications of single-cell transcriptome sequencing
العنوان: | Advanced analysis and applications of single-cell transcriptome sequencing |
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المؤلفون: | Zhao Ruohan, Bai Yicheng, Zhao Jingying, Hu Mei, Zhang Xinyan, Yang Min, Dou Tengfei, Jia Junjing |
المصدر: | All Life, Vol 16, Iss 1 (2023) |
بيانات النشر: | Taylor & Francis Group, 2023. |
سنة النشر: | 2023 |
المجموعة: | LCC:Biotechnology LCC:Life |
مصطلحات موضوعية: | single cell transcriptome sequencing, cellular communication, pseudo-time, scenic, functional enrichment, Biotechnology, TP248.13-248.65, Life, QH501-531 |
الوصف: | Single-cell transcriptome sequencing (scRNA-seq) is an unparalleled technology in the field of transcriptomics, which can study cells in a comprehensive and unbiased manner, thus characterizing complex biological processes at the cellular level. At the same time, scRNA-seq can produce a large amount of experimental data; therefore, the extraction of important information is required. In this review, we summarize the common applications of scRNA-seq analysis, such as of cellular communication, pseudo-timing, transcription factors, and functional enrichment, to mine cellular information and reveal the regulatory relationships between genes and trajectories of different cell lineages during development. We also describe the latest technological progress of scRNA-seq use in organoid, pathogenic gene variants, tumor tissues, stem cells, viruses, antibody preparation, and so on, in order to improve its applicability in future research in the life science field. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 2689-5307 26895293 |
Relation: | https://doaj.org/toc/2689-5307 |
DOI: | 10.1080/26895293.2023.2199140 |
URL الوصول: | https://doaj.org/article/1379010fb324498ea24a8ac3b59ce26e |
رقم الأكسشن: | edsdoj.1379010fb324498ea24a8ac3b59ce26e |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 26895307 26895293 |
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DOI: | 10.1080/26895293.2023.2199140 |