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Advanced analysis and applications of single-cell transcriptome sequencing

التفاصيل البيبلوغرافية
العنوان: Advanced analysis and applications of single-cell transcriptome sequencing
المؤلفون: Zhao Ruohan, Bai Yicheng, Zhao Jingying, Hu Mei, Zhang Xinyan, Yang Min, Dou Tengfei, Jia Junjing
المصدر: All Life, Vol 16, Iss 1 (2023)
بيانات النشر: Taylor & Francis Group, 2023.
سنة النشر: 2023
المجموعة: LCC:Biotechnology
LCC:Life
مصطلحات موضوعية: single cell transcriptome sequencing, cellular communication, pseudo-time, scenic, functional enrichment, Biotechnology, TP248.13-248.65, Life, QH501-531
الوصف: Single-cell transcriptome sequencing (scRNA-seq) is an unparalleled technology in the field of transcriptomics, which can study cells in a comprehensive and unbiased manner, thus characterizing complex biological processes at the cellular level. At the same time, scRNA-seq can produce a large amount of experimental data; therefore, the extraction of important information is required. In this review, we summarize the common applications of scRNA-seq analysis, such as of cellular communication, pseudo-timing, transcription factors, and functional enrichment, to mine cellular information and reveal the regulatory relationships between genes and trajectories of different cell lineages during development. We also describe the latest technological progress of scRNA-seq use in organoid, pathogenic gene variants, tumor tissues, stem cells, viruses, antibody preparation, and so on, in order to improve its applicability in future research in the life science field.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2689-5307
26895293
Relation: https://doaj.org/toc/2689-5307
DOI: 10.1080/26895293.2023.2199140
URL الوصول: https://doaj.org/article/1379010fb324498ea24a8ac3b59ce26e
رقم الأكسشن: edsdoj.1379010fb324498ea24a8ac3b59ce26e
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:26895307
26895293
DOI:10.1080/26895293.2023.2199140