دورية أكاديمية
أعرض في EDS

Paired box 8 facilitates the c-MYC related cell cycle progress in TP53-mutation uterine corpus endometrial carcinoma through interaction with DDX5

التفاصيل البيبلوغرافية
العنوان: Paired box 8 facilitates the c-MYC related cell cycle progress in TP53-mutation uterine corpus endometrial carcinoma through interaction with DDX5
المؤلفون: Ping Qiu, Youkun Jie, Cheng Ma, Huifeng Chen, Yunna Qin, Kaijia Tu, Liqun Wang, Ziyu Zhang
المصدر: Cell Death Discovery, Vol 8, Iss 1, Pp 1-11 (2022)
بيانات النشر: Nature Publishing Group, 2022.
سنة النشر: 2022
المجموعة: LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
LCC:Cytology
مصطلحات موضوعية: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671
الوصف: Abstract As a molecular marker of the female reproductive system, Paired Box 8 is widely used in pathological diagnosis of gynecological tumors, but it is not clear whether its expression level is related to the development of uterine corpus endometrial carcinoma and molecular subtype classifications. Here, we show that PAX8 is up-regulated in TP53 mutation category of UCEC, which is result from the low methylation level of PAX8 in UCEC. We have identified that genes connected to ribosome, lysosome, ribosome biogenesis and cell cycle as PAX8 targets and demonstrate that modulation of the PAX8-DDX5 interaction influences c-MYC related cell cycle and cell growth. Our work defines DDX5 as a critical PAX8 co-factor, places the PAX8-DDX5 interaction in biological context, and highlights PAX8 as a key point for development of novel anti-MYC therapies in TP53-mutation UCEC.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2058-7716
Relation: https://doaj.org/toc/2058-7716
DOI: 10.1038/s41420-022-01072-8
URL الوصول: https://doaj.org/article/13e23ba3b5d847a88d0e72f6871db261
رقم الأكسشن: edsdoj.13e23ba3b5d847a88d0e72f6871db261
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20587716
DOI:10.1038/s41420-022-01072-8