دورية أكاديمية
Effects of soy isoflavonoids (genistein and daidzein) on endometrial receptivity
| العنوان: | Effects of soy isoflavonoids (genistein and daidzein) on endometrial receptivity |
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| المؤلفون: | Erdem Toktay, Jale Selli, Muhammed Gurbuz, Tugba Tastan, Rustem Anil Ugan, Harun Un, Zekai Halici |
| المصدر: | Iranian Journal of Basic Medical Sciences, Vol 23, Iss 12, Pp 1603-1609 (2020) |
| بيانات النشر: | Mashhad University of Medical Sciences, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | daidzein, endometrial receptivity, genistein, rat, soy isoflavonoids, Medicine |
| الوصف: | Objective(s): This study aimed to examine the effects of genistein and daidzein on endometrial receptivity by histopathological, immunohistochemical, and biochemical techniques.Materials and Methods: In this study, 72 female Sprague-Dawley rats were randomly divided into 8 groups. The endometrial receptivity model was applied to identified groups. Experimental animals were given periorally 10 mg/kg and high 40 mg/kg doses of genistein and daidzein for 5 days by gavage. At the end of the experiment, uterine tissues were evaluated histopathologically, immunohistochemically, and biochemically. Results: When histopathological findings were examined, significant decreases in pinopod formation were observed in high dose genistein and daidzein groups. When compared with the endometrial receptivity group, immunohistochemical staining findings showed a significant decrease in the expression of integrin β3, integrin αvβ3, LIF, and HOXA10 and an increase in MUC 1 expression in the high dose of genistein and daidzein groups. In biochemical evaluations, it was determined that genistein and daidzein increased estrogen levels and decreased progesterone levels in a dose-dependent manner. Conclusion: Genistein and daidzein have a negative effect on endometrial receptivity. Therefore, individuals with a risk of infertility should pay attention to the consumption of genistein and daidzein. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2008-3866 2008-3874 |
| Relation: | https://ijbms.mums.ac.ir/article_16849_bc1a6ff346d9c435bdc5907eb2f5e9de.pdf; https://doaj.org/toc/2008-3866; https://doaj.org/toc/2008-3874 |
| DOI: | 10.22038/ijbms.2020.48294.11089 |
| URL الوصول: | https://doaj.org/article/13feea99512b422e8b117361429d4f9b |
| رقم الأكسشن: | edsdoj.13feea99512b422e8b117361429d4f9b |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20083866 20083874 |
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| DOI: | 10.22038/ijbms.2020.48294.11089 |