دورية أكاديمية
Antibiotic use and Influencing Factors Among Hospitalized Patients with COVID-19: A Multicenter Point-Prevalence Study from Turkey
| العنوان: | Antibiotic use and Influencing Factors Among Hospitalized Patients with COVID-19: A Multicenter Point-Prevalence Study from Turkey |
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| المؤلفون: | İrfan Şencan, Yasemin Çağ, Oğuz Karabay, Behice Kurtaran, Ertuğrul Güçlü, Aziz Öğütlü, Zehra Demirbaş, Dilek Bulut, Gülden Eser Karlıdağ, Merve Sefa Sayar, Ezgi Gizem Şibar, Oya Özlem Eren Kutsoylu, Gülnur Kul, Serpil Erol, Begüm Bektaş, Tülay Ünver Ulusoy, Semanur Kuzi, Meltem Tasbakan, Özge Yiğit, Nurgül Ceran, Ayşe Seza İnal, Pınar Ergen, Tansu Yamazhan, Hanife Uzar, Canan Ağalar |
| المصدر: | Balkan Medical Journal, Vol 39, Iss 3, Pp 209-217 (2022) |
| بيانات النشر: | Galenos Publishing House, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | Medicine |
| الوصف: | Background: Broad-spectrum empirical antimicrobials are frequently prescribed for patients with coronavirus disease 2019 (COVID-19) despite the lack of evidence for bacterial coinfection. Aims: We aimed to cross-sectionally determine the frequency of antibiotics use, type of antibiotics prescribed, and the factors influencing antibiotics use in hospitalized patients with COVID-19 confirmed by polymerase chain reaction. Study Design: The study was a national, multicenter, retrospective, and single-day point prevalence study. Methods: This was a national, multicenter, retrospective, and single-day point-prevalence study, conducted in the 24-h period between 00:00 and 24:00 on November 18, 2020, during the start of the second COVID-19 peak in Turkey. Results: A total of 1500 patients hospitalized with a diagnosis of COVID-19 were included in the study. The mean age ± standard deviation of the patients was 65.0 ± 15.5, and 56.2% (n = 843) of these patients were men. Of these hospitalized patients, 11.9% (n = 178) were undergoing invasive mechanical ventilation or ECMO. It was observed that 1118 (74.5%) patients were receiving antibiotics, of which 416 (37.2%) were prescribed a combination of antibiotics. In total, 71.2% of the patients had neither a clinical diagnosis nor microbiological evidence for prescribing antibiotics. In the multivariate logistic regression analysis, hospitalization in a state hospital (p < 0.001), requiring any supplemental oxygen (p = 0.005), presence of moderate/diffuse lung involvement (p < 0.001), C-reactive protein > 10 ULT coefficient (p < 0.001), lymphocyte count < 800 (p = 0.007), and clinical diagnosis and/or confirmation by culture (p < 0.001) were found to be independent factors associated with increased antibiotic use. Conclusion: The necessity of empirical antibiotics use in patients with COVID-19 should be reconsidered according to their clinical, imaging, and laboratory findings. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2146-3123 2146-3131 |
| Relation: | http://www.balkanmedicaljournal.org/abstract.php?lang=en&id=2399; https://doaj.org/toc/2146-3123; https://doaj.org/toc/2146-3131 |
| DOI: | 10.4274/balkanmedj.galenos.2022.2021-11-62 |
| URL الوصول: | https://doaj.org/article/1402341b3ec74327b912f7d18baba1b8 |
| رقم الأكسشن: | edsdoj.1402341b3ec74327b912f7d18baba1b8 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 21463123 21463131 |
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| DOI: | 10.4274/balkanmedj.galenos.2022.2021-11-62 |