دورية أكاديمية
Comparative Study of Adjuvant Temozolomide Six Cycles Versus Extended 12 Cycles in Newly Diagnosed Glioblastoma Multiforme
| العنوان: | Comparative Study of Adjuvant Temozolomide Six Cycles Versus Extended 12 Cycles in Newly Diagnosed Glioblastoma Multiforme |
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| المؤلفون: | Menal Bhandari, Ajeet Kumar Gandhi, Bharti Devnani, Pavnesh Kumar, Daya Nand Sharma, Pramod Kumar Julka |
| المصدر: | Journal of Clinical and Diagnostic Research, Vol 11, Iss 5, Pp XC04-XC08 (2017) |
| بيانات النشر: | JCDR Research and Publications Private Limited, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | extended chemotherapy, overall survival, radiotherapy, Medicine |
| الوصف: | Introduction: Studies have shown promising survival with the use of Extended Temozolomide (E-TMZ) as compared to Conventional six cycles of Temozolomide (C-TMZ) in malignant gliomas; however, the reports are mostly limited to retrospective studies with significant bias. Aim: This study assesses the impact of six versus 12 cycles of adjuvant Temozolomide (TMZ) on Overall Survival (OS) in newly diagnosed postoperative patients of Glioblastoma Multiforme (GBM). Materials and Methods: Between January 2012 and July 2013, 40 postoperative patients of GBM between age 18-65 years and Karnofsky Performance Score (KPS) ≥70 were included. Patients were randomized to receive radiation (60 Gray in 30 fractions over six weeks) with concomitant TMZ (75 mg/m2 /day) and adjuvant therapy with either six (C-TMZ arm) or 12 cycles (E-TMZ arm) of TMZ (150-200 mg/m2 for five days, repeated four weekly). Twenty patients were treated in each arm. Toxicity was assessed using Common Terminology Criteria for Adverse Events (CTCAE) version 3.0. OS and Progression Free Survival (PFS) were calculated from the time of diagnosis. Kaplan Meier method was used for survival analysis. A p-value of |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2249-782X 0973-709X |
| Relation: | https://jcdr.net/articles/PDF/9945/27611_CE(RA1)_F(T)_PF1(SY_SS)_PFA(SY_SS).pdf; https://doaj.org/toc/2249-782X; https://doaj.org/toc/0973-709X |
| DOI: | 10.7860/JCDR/2017/27611.9945 |
| URL الوصول: | https://doaj.org/article/ca1426e7b1314452b557b522921f17ab |
| رقم الأكسشن: | edsdoj.1426e7b1314452b557b522921f17ab |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2249782X 0973709X |
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| DOI: | 10.7860/JCDR/2017/27611.9945 |