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Design and Characterization of Chitosan-Based Smart Injectable Hydrogel for Improved Sustained Release of Antinarcotics

التفاصيل البيبلوغرافية
العنوان: Design and Characterization of Chitosan-Based Smart Injectable Hydrogel for Improved Sustained Release of Antinarcotics
المؤلفون: Maryam Aftab, Fatima Javed, Sajjad Haider, Rawaiz Khan, Salah Uddin Khan, Kamran Alam, Afreenish Amir, Faheem Ullah, Naseer Ali Shah
المصدر: Pharmaceuticals, Vol 17, Iss 6, p 749 (2024)
بيانات النشر: MDPI AG, 2024.
سنة النشر: 2024
المجموعة: LCC:Medicine
LCC:Pharmacy and materia medica
مصطلحات موضوعية: injectable hydrogel, chitosan, sustained release, naltrexone, disulfiram, ethanol, Medicine, Pharmacy and materia medica, RS1-441
الوصف: The treatment adherence of narcotics-addicted individuals with reduced incidences of relapse can be enhanced by a sustained drug release formulation of antinarcotics. So far, different drug formulations have been reported with sustained drug release periods of 28 and 35 days. To further enhance this duration, different formulations of injectable hydrogels (IHs) have been developed by combining low molecular weight (LMW) and high molecular weight (HMW) chitosan (CS) with guar gum (GG) and crosslinking them by sodium bi phosphate dibasic. The structural, morphological, and physicochemical properties of LMW-CS IH, and HMW-CS IH were evaluated using Fourier transform infrared spectroscopy (FT-IR), thermo-gravimetric analysis (TGA), scanning electron microscopy (SEM), and rheological, swelling, and biodegradation analysis. The HMW-CS IH showed high crosslinking, increased thermal stability, high mechanical strength, elevated swelling, and low biodegradation. The antinarcotic drugs naltrexone (NTX) and disulfiram (DSF) were loaded separately into the HMW-CS IH and LMW-CS IH. The release of NTX and DSF was investigated in phosphate buffer saline (PBS) and ethanol (0.3%, 0.4%, and 0.5%) over a 56-day period using an UV spectrophotometer. The drug release data were tested in zero-order, first-order, and Korsemeyer–Peppas mathematical models. In PBS, all prepared formulations followed non-Fickian drug release, while in ethanol, only NTX HMW-CS IH followed non-Fickian release in all three different concentrations of ethanol.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1424-8247
Relation: https://www.mdpi.com/1424-8247/17/6/749; https://doaj.org/toc/1424-8247
DOI: 10.3390/ph17060749
URL الوصول: https://doaj.org/article/14297a625bf64ecb84ae4f0cf7e6b659
رقم الأكسشن: edsdoj.14297a625bf64ecb84ae4f0cf7e6b659
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14248247
DOI:10.3390/ph17060749