دورية أكاديمية
The decisive role of fumarase: Responsive signaling to glucose deficiency
| العنوان: | The decisive role of fumarase: Responsive signaling to glucose deficiency |
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| المؤلفون: | Qiujing Yu, Ting Wang, Yuhui Jiang |
| المصدر: | Molecular & Cellular Oncology, Vol 5, Iss 4 (2018) |
| بيانات النشر: | Taylor & Francis Group, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | ampk, fumarase, glucose deficiency, o-glcnac transferase, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Our recent study shows that AMPK normally phosphorates fumarase (FH) at Ser75 under glucose deprivation, resulting in FH-ATF2 complex formation that facilitates transcription for cell growth arrest. Meanwhile, O-GlcNAc transferase can compete with AMPK to O-GlcNAcylate FH. In tumor cells, FH is highly O-GlcNAcylated and is proinhibited from AMPK-ATF2 signaling. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2372-3556 23723556 |
| Relation: | https://doaj.org/toc/2372-3556 |
| DOI: | 10.1080/23723556.2017.1363848 |
| URL الوصول: | https://doaj.org/article/142b7b004ea84a619879a8fcc06d5693 |
| رقم الأكسشن: | edsdoj.142b7b004ea84a619879a8fcc06d5693 |
| قاعدة البيانات: | Directory of Open Access Journals |
PDF full text from Publisher | تدمد: | 23723556 |
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| DOI: | 10.1080/23723556.2017.1363848 |