دورية أكاديمية
Extrahepatic Angiogenesis: A Potential Common Pathophysiological Basis of Multiple Organ Dysfunction in Rats with Cholestasis Cirrhosis
| العنوان: | Extrahepatic Angiogenesis: A Potential Common Pathophysiological Basis of Multiple Organ Dysfunction in Rats with Cholestasis Cirrhosis |
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| المؤلفون: | Dandan Wang, Chunyong Yang, Ziyang Zeng, Xianfeng Wu, Hao Liang, Xiaoyan Hu, Yizhu Sun, Junhong Li, Jun Li, Xin Shu, Zhiyong Yang, Xiaobo Wang, Karine Belguise, Yujie Li, Bin Yi |
| المصدر: | Frontiers in Bioscience-Landmark, Vol 28, Iss 10, p 272 (2023) |
| بيانات النشر: | IMR Press, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Biochemistry LCC:Biology (General) |
| مصطلحات موضوعية: | angiogenesis, cholestatic cirrhosis, vascular endothelial growth factor, dysfunction, Biochemistry, QD415-436, Biology (General), QH301-705.5 |
| الوصف: | Background: In addition to intrahepatic angiogenesis, patients with cholestasis cirrhosis develop extrahepatic vasculature disorders and functional disturbances of multiple organ systems. Without effective intervention, these vascular disorders will eventually turn into multiple organs vascular syndromes, including the brain, lung and other organ systems. However, studies on the pathogenesis of vascular alterations among extrahepatic organ disturbances are still carried out separately, which hampered the successful translation of preclinical studies to the human setting and required further mechanistic insight into these complications. This study aims to investigate the relationship between extrahepatic angiogenesis and multiple organ impairment, and whether the vascular endothelial growth factor (VEGF) family members and their receptors are involved in this process. Methods: Pathological changes of the multiple organs were determined by histopathological and immunohistochemical staining in the established common bile duct ligation (CBDL) rats, and angiogenesis was estimated by microvessel density (MVD). Levels of the VEGF family members and their receptors in the serum and organ tissues were also measured by using enzyme-linked immunosorbent assays. Results: The MVD and VEGF family members and their receptors were significantly increased in CBDL rats with multiple organ injury, especially in the liver, lung and cerebral cortex. Meanwhile, we noticed moderate elevation of soluble receptor of the vascular endothelial growth factor-1 (sFlt-1) in the liver, lung, and cerebral cortex, whereas the levels of placental growth factor (PLGF) increased significantly. Conclusions: Extrahepatic angiogenesis may represent a common pathophysiological basis for multiple organ dysfunction and the sFlt-1/PLGF ratio could offer an avenue for further studies to target extrahepatic angiogenesis in cholestatic cirrhosis. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2768-6701 14544784 |
| Relation: | https://www.imrpress.com/journal/FBL/28/10/10.31083/j.fbl2810272; https://doaj.org/toc/2768-6701 |
| DOI: | 10.31083/j.fbl2810272 |
| URL الوصول: | https://doaj.org/article/145447843e554dd1a537ecf437702278 |
| رقم الأكسشن: | edsdoj.145447843e554dd1a537ecf437702278 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 27686701 14544784 |
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| DOI: | 10.31083/j.fbl2810272 |