دورية أكاديمية
Clinical characteristics of children and adolescents with severe therapy-resistant asthma in Brazil
| العنوان: | Clinical characteristics of children and adolescents with severe therapy-resistant asthma in Brazil |
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| المؤلفون: | Andrea Mendonça Rodrigues, Cristian Roncada, Giovana Santos, João Paulo Heinzmann-Filho, Rodrigo Godinho de Souza, Mauro Henrique Moraes Vargas, Leonardo Araújo Pinto, Marcus Herbert Jones, Renato Tetelbom Stein, Paulo Márcio Pitrez |
| المصدر: | Jornal Brasileiro de Pneumologia, Vol 41, Iss 4, Pp 343-350 (2015) |
| بيانات النشر: | Sociedade Brasileira de Pneumologia e Tisiologia, 2015. |
| سنة النشر: | 2015 |
| المجموعة: | LCC:Diseases of the respiratory system |
| مصطلحات موضوعية: | Alergia e imunologia, Inflamação, Escarro, Testes de função respiratória, Diseases of the respiratory system, RC705-779 |
| الوصف: | AbstractObjective: To describe the clinical characteristics, lung function, radiological findings, and the inflammatory cell profile in induced sputum in children and adolescents with severe therapy-resistant asthma (STRA) treated at a referral center in southern Brazil.Methods: We retrospectively analyzed children and adolescents (3-18 years of age) with uncontrolled STRA treated with high-dose inhaled corticosteroids and long-acting β2 agonists. We prospectively collected data on disease control, lung function, skin test reactivity to allergens, the inflammatory cell profile in induced sputum, chest CT findings, and esophageal pH monitoring results.Results: We analyzed 21 patients (mean age, 9.2 ± 2.98 years). Of those, 18 (86%) were atopic. Most had uncontrolled asthma and near-normal baseline lung function. In 4 and 7, induced sputum was found to be eosinophilic and neutrophilic, respectively; the inflammatory cell profile in induced sputum having changed in 67% of those in whom induced sputum analysis was repeated. Of the 8 patients receiving treatment with omalizumab (an anti-IgE antibody), 7 (87.5%) showed significant improvement in quality of life, as well as significant reductions in the numbers of exacerbations and hospitalizations.Conclusions: Children with STRA present with near-normal lung function and a variable airway inflammatory pattern during clinical follow-up, showing a significant clinical response to omalizumab. In children, STRA differs from that seen in adults, further studies being required in order to gain a better understanding of the disease mechanisms. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Portuguese |
| تدمد: | 1806-3756 1806-3713 |
| Relation: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132015000400343&lng=en&tlng=en; https://doaj.org/toc/1806-3756 |
| DOI: | 10.1590/S1806-37132015000004462 |
| URL الوصول: | https://doaj.org/article/14ad1d3d31834b22b2a9c0b014a58934 |
| رقم الأكسشن: | edsdoj.14ad1d3d31834b22b2a9c0b014a58934 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 18063756 18063713 |
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| DOI: | 10.1590/S1806-37132015000004462 |