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Proximal tubule-derived exosomes contribute to mesangial cell injury in diabetic nephropathy via miR-92a-1-5p transfer

التفاصيل البيبلوغرافية
العنوان: Proximal tubule-derived exosomes contribute to mesangial cell injury in diabetic nephropathy via miR-92a-1-5p transfer
المؤلفون: Yi-Chun Tsai, Mei-Chuan Kuo, Wei-Wen Hung, Ping-Hsun Wu, Wei-An Chang, Ling-Yu Wu, Su-Chu Lee, Ya-Ling Hsu
المصدر: Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-19 (2023)
بيانات النشر: BMC, 2023.
سنة النشر: 2023
المجموعة: LCC:Medicine
LCC:Cytology
مصطلحات موضوعية: Exosome, miR-92a-1-5p, Mesangial cell, Proximal tubular epithelial cell, Myofibroblast transdifferentiation, ER stress, Medicine, Cytology, QH573-671
الوصف: Plain English Summary Diabetic nephropathy (DN) has been the leading cause of end-stage renal disease worldwide. Exosomes play a principle role in cross-talk of kidney cells and further affect the onset or progression of DN. This study firstly demonstrated the communication between proximal tubular epithelial cells (PTECs) and mesangial cells (MCs) through exosome transmission. PTEC-released exosomal 92a-1-5p induced endoplasmic reticulum stress and epithelial-mesenchymal transition in MCs through reticulocalbin-3 modulation. Kidney damage was rescued in DN mice after treatment with miR-92a-1-5p inhibitor. Moreover, urinary exosomal miR-92a-1-5p could predict DN progression in type 2 diabetic patients. These findings prove the impact of exosomal miR-92a-1-5p on pathophysiologic mechanisms and its potential use in clinical care and prediction of DN.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1478-811X
Relation: https://doaj.org/toc/1478-811X
DOI: 10.1186/s12964-022-00997-y
URL الوصول: https://doaj.org/article/14b1964164be426db38e9f8cc04f6718
رقم الأكسشن: edsdoj.14b1964164be426db38e9f8cc04f6718
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:1478811X
DOI:10.1186/s12964-022-00997-y