دورية أكاديمية
أعرض في EDS

Targeting the integrated stress response in hematologic malignancies

التفاصيل البيبلوغرافية
العنوان: Targeting the integrated stress response in hematologic malignancies
المؤلفون: Gus O. Nwosu, Jason A. Powell, Stuart M. Pitson
المصدر: Experimental Hematology & Oncology, Vol 11, Iss 1, Pp 1-15 (2022)
بيانات النشر: BMC, 2022.
سنة النشر: 2022
المجموعة: LCC:Diseases of the blood and blood-forming organs
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
مصطلحات موضوعية: Integrated stress response, PERK, PKR, GCN2, HRI, ATF4, Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
الوصف: Abstract While numerous targeted therapies have been recently adopted to improve the treatment of hematologic malignancies, acquired or intrinsic resistance poses a significant obstacle to their efficacy. Thus, there is increasing need to identify novel, targetable pathways to further improve therapy for these diseases. The integrated stress response is a signaling pathway activated in cancer cells in response to both dysregulated growth and metabolism, and also following exposure to many therapies that appears one such targetable pathway for improved treatment of these diseases. In this review, we discuss the role of the integrated stress response in the biology of hematologic malignancies, its critical involvement in the mechanism of action of targeted therapies, and as a target for pharmacologic modulation as a novel strategy for the treatment of hematologic malignancies.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2162-3619
Relation: https://doaj.org/toc/2162-3619
DOI: 10.1186/s40164-022-00348-0
URL الوصول: https://doaj.org/article/14caca18f57e45f690dcca7bbe4e8ffa
رقم الأكسشن: edsdoj.14caca18f57e45f690dcca7bbe4e8ffa
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:21623619
DOI:10.1186/s40164-022-00348-0