دورية أكاديمية
Liposomal topical capsaicin in post-herpetic neuralgia: a safety pilot study
| العنوان: | Liposomal topical capsaicin in post-herpetic neuralgia: a safety pilot study |
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| المؤلفون: | Manoel Jacobsen Teixeira, Luciana Mendes Bahia Menezes, Valquiria Silva, Ricardo Galhardoni, José Sasson, Massako Okada, Kleber Paiva Duarte, Lin T. Yeng, Daniel Ciampi de Andrade |
| المصدر: | Arquivos de Neuro-Psiquiatria, Vol 73, Iss 3, Pp 237-240 (2015) |
| بيانات النشر: | Academia Brasileira de Neurologia (ABNEURO), 2015. |
| سنة النشر: | 2015 |
| المجموعة: | LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| مصطلحات موضوعية: | capsaicina, dor, neuralgia, analgesia, efeitos adversos, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| الوصف: | Topical treatments have gained popularity for general use as an adjunct to systemic drugs in neuropathic pain, but their use produces variable clinical results and local adverse events. Objective To evaluate the safety and analgesic effect of a formulation of liposomal capsaicin (LC) (0.025%) in patients with post herpetic neuralgia (PHN). Method Patients who remained symptomatic after first-and second-line treatment were randomized to receive LC for six weeks in a placebo-controlled, crossover design study. Clinical assessment was performed at baseline, in the second, fourth and sixth week of treatment. Results Thirteen patients completed both treatment periods. Visual Analog Scale (VAS) was significantly decreased after the end of the study (p = 0.008), however the effect of treatment was not significant (p = 0.076). There was no difference on global impression of change and other pain characteristics. LC was safe and well tolerated. However, at the concentration used, its analgesic effects were marginal and not significant. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1678-4227 0004-282X |
| Relation: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000300237&lng=en&tlng=en; https://doaj.org/toc/1678-4227 |
| DOI: | 10.1590/0004-282X20140232 |
| URL الوصول: | https://doaj.org/article/14cc704982554ffb9125278faa9a426f |
| رقم الأكسشن: | edsdoj.14cc704982554ffb9125278faa9a426f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16784227 0004282X |
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| DOI: | 10.1590/0004-282X20140232 |