Pogz deficiency leads to transcription dysregulation and impaired cerebellar activity underlying autism-like behavior in mice

التفاصيل البيبلوغرافية
العنوان:	Pogz deficiency leads to transcription dysregulation and impaired cerebellar activity underlying autism-like behavior in mice
المؤلفون:	Reut Suliman-Lavie, Ben Title, Yahel Cohen, Nanako Hamada, Maayan Tal, Nitzan Tal, Galya Monderer-Rothkoff, Bjorg Gudmundsdottir, Kristbjorn O. Gudmundsson, Jonathan R. Keller, Guo-Jen Huang, Koh-ichi Nagata, Yosef Yarom, Sagiv Shifman
المصدر:	Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
بيانات النشر:	Nature Portfolio, 2020.
سنة النشر:	2020
المجموعة:	LCC:Science
مصطلحات موضوعية:	Science
الوصف:	POGZ is an autism spectrum disorder risk gene. How POGZ mutations result in ASD is unclear and animal models are lacking. Here, the authors generate a brain specific Pogz deficient mouse presenting ASD-like behaviour and show the effects of Pogz deficiency in the cerebellum.
نوع الوثيقة:	article
وصف الملف:	electronic resource
اللغة:	English
تدمد:	2041-1723
Relation:	https://doaj.org/toc/2041-1723
DOI:	10.1038/s41467-020-19577-0
URL الوصول:	https://doaj.org/article/14ea55860cc94204933e8e502705deac
رقم الأكسشن:	edsdoj.14ea55860cc94204933e8e502705deac
قاعدة البيانات:	Directory of Open Access Journals

الوصف
تدمد:	20411723
DOI:	10.1038/s41467-020-19577-0