دورية أكاديمية
Safety of TCMCB07, a melanocortin‐4 antagonist peptide, in dogs with naturally occurring cachexia
| العنوان: | Safety of TCMCB07, a melanocortin‐4 antagonist peptide, in dogs with naturally occurring cachexia |
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| المؤلفون: | Sandra M. Axiak‐Bechtel, Stacey B. Leach, Jessica R. Newton‐Northup, Rowan J. Milner, Stacey A. Fox‐Alvarez, Lana I. Fagman, Kaylee A. Young, Deborah J. Tate, Zachary M. Wright, John D. Chretin, Justin W. Allen, Sean K. Yoshimoto, Kimberly A. Selting, Brian K. Flesner, Carrie R. White, Tracy Mills, Michael Aherne, Philip J. Bergman, LeAnn Qi, Kenneth A. Gruber, Michael F. Callahan |
| المصدر: | Journal of Veterinary Internal Medicine, Vol 37, Iss 6, Pp 2344-2355 (2023) |
| بيانات النشر: | Wiley, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Veterinary medicine |
| مصطلحات موضوعية: | anorexia, canine, emaciation, metabolism, therapy, Veterinary medicine, SF600-1100 |
| الوصف: | Abstract Background The melanocortin 4 antagonist TCMCB07 is safe and effective in reversing cachexia caused by sepsis or cancer in rodents. The safety and pharmacokinetics of TCMCB07 are demonstrated in healthy beagle dogs. Hypothesis/Objectives The objectives of this study were to investigate the safety, peak plasma concentrations, and potential for efficacy of TCMCB07 in pet dogs with naturally occurring cachexia over a 4‐week time period. Animals Fourteen dogs with cachexia of any underlying cause, except cancer of the oral cavity or gastrointestinal tract, were eligible for enrollment with informed client consent. Methods This study was a prospective, 1‐armed open‐label trial. Physical examination, complete blood count, chemistry panel, and owner‐assessed quality of life surveys were checked at weeks 1, 2, and 4. Due to potential for bradycardia and hypotension, Holter monitoring and blood pressure evaluations were scheduled at pre‐enrollment and week 4. Results Fourteen dogs completed the trial. Significant changes detected included increased mean body weight (18.6‐19.5 kg, P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1939-1676 0891-6640 |
| Relation: | https://doaj.org/toc/0891-6640; https://doaj.org/toc/1939-1676 |
| DOI: | 10.1111/jvim.16915 |
| URL الوصول: | https://doaj.org/article/15500eb735e64a8094068773cb02e744 |
| رقم الأكسشن: | edsdoj.15500eb735e64a8094068773cb02e744 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19391676 08916640 |
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| DOI: | 10.1111/jvim.16915 |