دورية أكاديمية
Low-frequency MR elastography reveals altered deep gray matter viscoelasticity in multiple sclerosis
| العنوان: | Low-frequency MR elastography reveals altered deep gray matter viscoelasticity in multiple sclerosis |
|---|---|
| المؤلفون: | Christian Kiss, Sebastian Wurth, Bettina Heschl, Michael Khalil, Thomas Gattringer, Christian Enzinger, Stefan Ropele |
| المصدر: | NeuroImage: Clinical, Vol 42, Iss , Pp 103606- (2024) |
| بيانات النشر: | Elsevier, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Computer applications to medicine. Medical informatics LCC:Neurology. Diseases of the nervous system |
| مصطلحات موضوعية: | Magnetic resonance elastography, Multiple sclerosis, Viscoelasticity, Stiffness, Brain, Deep Gray Matter, Computer applications to medicine. Medical informatics, R858-859.7, Neurology. Diseases of the nervous system, RC346-429 |
| الوصف: | Introduction: Brain viscoelasticity as assessed by magnetic resonance elastography (MRE) has been discussed as a promising surrogate of microstructural alterations due to neurodegenerative processes. Existing studies indicate that multiple sclerosis (MS) is associated with a global reduction in brain stiffness. However, no study to date systematically investigated the MS-related characteristics of brain viscoelasticity separately in normal-appearing white matter (NAWM), deep gray matter (DGM) and T2-hyperintense white matter (WM) lesions. Methods: 70 MS patients and 42 healthy volunteers underwent whole-cerebral MRE using a stimulated echo sequence (DENSE) with a low-frequency mechanical excitation at 20 Hertz. The magnitude |G∗| (Pa) and phase angle φ (rad) of the complex shear modulus G∗ were reconstructed by multifrequency dual elasto-visco (MDEV) inversion and related to structural imaging and clinical parameters. Results: We observed φ in the thalamus to be higher by 4.3 % in patients relative to healthy controls (1.11 ± 0.07 vs. 1.06 ± 0.07, p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2213-1582 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2213158224000457; https://doaj.org/toc/2213-1582 |
| DOI: | 10.1016/j.nicl.2024.103606 |
| URL الوصول: | https://doaj.org/article/155f56633edc43f288ca64e1ddbddf30 |
| رقم الأكسشن: | edsdoj.155f56633edc43f288ca64e1ddbddf30 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 22131582 |
|---|---|
| DOI: | 10.1016/j.nicl.2024.103606 |