دورية أكاديمية
Zinc and vitamin A supplementation fails to reduce sputum conversion time in severely malnourished pulmonary tuberculosis patients in Indonesia
| العنوان: | Zinc and vitamin A supplementation fails to reduce sputum conversion time in severely malnourished pulmonary tuberculosis patients in Indonesia |
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| المؤلفون: | van der Velden Koos, Bor Hans, Darmawidjaja Nining, Salean Michael, Suratih Ni Made, Karyadi Elvina, Pakasi Trevino A, Dolmans Wil MV, van der Meer Jos WM |
| المصدر: | Nutrition Journal, Vol 9, Iss 1, p 41 (2010) |
| بيانات النشر: | BMC, 2010. |
| سنة النشر: | 2010 |
| المجموعة: | LCC:Nutrition. Foods and food supply LCC:Nutritional diseases. Deficiency diseases |
| مصطلحات موضوعية: | Nutrition. Foods and food supply, TX341-641, Nutritional diseases. Deficiency diseases, RC620-627 |
| الوصف: | Abstract Background A previous study showed that combination of zinc and vitamin A reduced sputum conversion time in pulmonary tuberculosis (TB) patients. Objective We studied the efficacy of which single micronutrient contributed more to the sputum conversion time. Methods In a double-blind randomized community trial, newly sputum smear positive pulmonary TB patients were assigned randomly to receive zinc, vitamin A, zinc + vitamin A or placebo on top of TB treatment. Patients were asked to deliver their sputum on weekly basis to measure positivity of the bacteria. Nutritional status, chest x-ray, hemoglobin, C-reactive protein (CRP), retinol and zinc level were examined prior to, after 2 and 6 months of treatment. Results Initially, 300 patients were enrolled, and 255 finished the treatment. Most patients were severely malnourished (mean BMI 16.5 ± 2.2 Kg/m2). Patients in the zinc + vitamin A group showed earlier sputum conversion time (mean 1.9 weeks) compared with that in the other groups; however the difference was not significant. Also, no benefit could be demonstrated of any of the used supplementations on clinical, nutritional, chest x-ray, or laboratory findings. Conclusions This study among severely malnourished TB patients, did not confirm that single or combined supplementation of zinc and vitamin A significantly reduced sputum conversion time or had other significant benefit. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1475-2891 |
| Relation: | http://www.nutritionj.com/content/9/1/41; https://doaj.org/toc/1475-2891 |
| DOI: | 10.1186/1475-2891-9-41 |
| URL الوصول: | https://doaj.org/article/e15766622a724f4e85d5582282ab6a97 |
| رقم الأكسشن: | edsdoj.15766622a724f4e85d5582282ab6a97 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 14752891 |
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| DOI: | 10.1186/1475-2891-9-41 |