دورية أكاديمية
أعرض في EDS

Analysis of Differentially Expressed Proteins in Self-Paired Sera of Advanced Non-small Cell Lung Cancer Patients Responsive to Gefin

التفاصيل البيبلوغرافية
العنوان: Analysis of Differentially Expressed Proteins in Self-Paired Sera of Advanced Non-small Cell Lung Cancer Patients Responsive to Gefin
المؤلفون: Ying HUANG, Shiliang CHEN, Hongyan TANG, Shejuan AN, Jiaying LIN, Ailin GUO, Yujuan HUANG, Jinji YANG, Xuchao ZHANG, Xuening YANG, Yilong WU
المصدر: Chinese Journal of Lung Cancer, Vol 12, Iss 7, Pp 765-769 (2009)
بيانات النشر: Chinese Anti-Cancer Association; Chinese Antituberculosis Association, 2009.
سنة النشر: 2009
المجموعة: LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
مصطلحات موضوعية: Lung neoplasms, Epidermal growth factor receptor, Tyrosine kinase inhibitor, Serum protein, Biomarker, Gefitinib, Matrix-assisted laser desorption ionization time-of-flight mass spectrometry, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
الوصف: Background and objective All the advanced NSCLC patients that received EGFR-TKI therapy will eventually relapse after a period of efficacy. The aim of this study is to investigate the serum biomarkers as potential predictive factors for the efficacy of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) targeted therapy in advanced non-small cell lung cancer. Methods Twenty self-paired serum samples were collected from 9 advanced NSCLC patients that evaluated as disease control (SD or PR) after gefinitib therapy, at the time points of before and after gefinitib treatment but 2 weeks before being evaluated as disease progress. All samples were pre-separated by WCX microbeads, and then detected on the MALDI-TOF-MS platform of Bruker AutoflexTM. ClinProTools (Version: 2.1) was used to analyze the differentially expressed proteins. Results There were 7 protein peaks (m/z), 3242.09, 8 690.36, 2 952.64, 3 224.04, 1 450.51, 1 887.8 and 3 935.73 found statistically differentially expressed between the self-paired samples. Three proteins (3 242.09, 2 952.64 and 3 224.04) were down-regulated and four proteins (8 690.36, 1 450.51, 1 887.8 and 3 935.73) up-regulated in gefinitib treated sera. Conclusion The data here suggest that several specific protein peaks might indicate gefinitib resistance, yet the identities of these proteins and the mechanisms underlying the responsiveness to gefinitib treatment need further investigation.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: Chinese
تدمد: 1009-3419
1999-6187
Relation: http://www.lungca.org/index.php?journal=01&page=article&op=viewFile&path[]=10.3779%2Fj.issn.1009-3419.2009.07.018&path[]=944; https://doaj.org/toc/1009-3419; https://doaj.org/toc/1999-6187
URL الوصول: https://doaj.org/article/159d276e0b42446c80700a949c0312af
رقم الأكسشن: edsdoj.159d276e0b42446c80700a949c0312af
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:10093419
19996187