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Increased regulatory B cells are involved in immune evasion in patients with gastric cancer

التفاصيل البيبلوغرافية
العنوان: Increased regulatory B cells are involved in immune evasion in patients with gastric cancer
المؤلفون: Yuki Murakami, Hiroaki Saito, Shota Shimizu, Yusuke Kono, Yuji Shishido, Kozo Miyatani, Tomoyuki Matsunaga, Yoji Fukumoto, Keigo Ashida, Tomohiko Sakabe, Yuji Nakayama, Yoshiyuki Fujiwara
المصدر: Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
بيانات النشر: Nature Portfolio, 2019.
سنة النشر: 2019
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Abstract Accumulating evidence has indicated that immune regulatory cells are involved in the establishment of tumoral immune evasion. However, the role of regulatory B cells (Bregs) in this remains unclear. Here, we identified a role for Bregs in immune evasion in gastric cancer (GC) patients. The frequency of peripheral Bregs was significantly higher in GC patients than in healthy controls (P = 0.0023). Moreover, the frequency of CD19+CD24hiCD27+ B cells in GC tissue was significantly higher than in peripheral blood and healthy gastric tissue. Carboxyfluorescein succinimidyl ester labeling revealed that CD19+CD24hiCD27+ B cells could suppress the proliferation of autologous CD4+ T cells. Moreover, CD19+CD24hiCD27+ B cells inhibited the production of interferon-gamma by CD4+ T cells. Double staining immunohistochemistry of interleukin-10 and CD19 revealed 5-year overall survival rates of 65.4% and 13.3% in BregLow and BregHigh groups, respectively (P
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2045-2322
Relation: https://doaj.org/toc/2045-2322
DOI: 10.1038/s41598-019-49581-4
URL الوصول: https://doaj.org/article/aa15a0864ffe4b4f925729f8092258a8
رقم الأكسشن: edsdoj.15a0864ffe4b4f925729f8092258a8
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20452322
DOI:10.1038/s41598-019-49581-4