دورية أكاديمية
A meta‐analysis of left ventricular dysfunction in ankylosing spondylitis
| العنوان: | A meta‐analysis of left ventricular dysfunction in ankylosing spondylitis |
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| المؤلفون: | Olayiwola Bolaji, Osejie Oriaifo, Olanrewaju Adabale, Arthur Dilibe, Krishna Kuruvada, Faizal Ouedraogo, Ebubechukwu Ezeh, Ambica Nair, Titilope Olanipekun, Sula Mazimba, Chadi Alraies |
| المصدر: | The Journal of Clinical Hypertension, Vol 26, Iss 7, Pp 772-788 (2024) |
| بيانات النشر: | Wiley, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Diseases of the circulatory (Cardiovascular) system |
| مصطلحات موضوعية: | ankylosing spondylitis, cardiovascular disease, hypertension (HTN), inflammatory arthritis, left ventricular dysfunction, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| الوصف: | Abstract Ankylosing spondylitis (AS) is a chronic inflammatory arthritis affecting the spine, presenting a considerable morbidity risk. Although evidence consistently indicates an elevated risk of ischemic heart disease among AS patients, debates persist regarding the likelihood of these patients developing left ventricular dysfunction (LVD). Our investigation aimed to determine whether individuals with AS face a greater risk of LVD compared to the general population. To accomplish this, we identified studies exploring LVD in AS patients across five major databases and Google Scholar. Initially, 431 studies were identified, of which 30 met the inclusion criteria, collectively involving 2933 participants. Results show that AS patients had: (1) poorer Ejection Fraction (EF) [mean difference (MD): −0.92% (95% CI: −1.25 to −0.59)], (2) impaired Early (E) and Late (atrial—A) ventricular filling velocity (E/A) ratio [MD: −0.10 m/s (95% CI: −0.13 to −0.08)], (3) prolonged deceleration time (DT) [MD: 12.30 ms (95% CI: 9.23–15.36)] and, (4) a longer mean isovolumetric relaxation time (IVRT) [MD: 8.14 ms (95% CI: 6.58–9.70)] compared to controls. Though AS patients show increased risks of both systolic and diastolic LVD, we found no significant differences were observed in systolic blood pressure [MD: 0.32 mmHg (95% Confidence Interval (CI): −2.09 to 2.73)] or diastolic blood pressure [MD: 0.30 mmHg (95% CI: −0.40 to 1.01)] compared to the general population. This study reinforces AS patients' susceptibility to LVD without a notable difference in HTN risk. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1751-7176 1524-6175 |
| Relation: | https://doaj.org/toc/1524-6175; https://doaj.org/toc/1751-7176 |
| DOI: | 10.1111/jch.14827 |
| URL الوصول: | https://doaj.org/article/15c9bcfe2d5945af88a482ec6a0a69e8 |
| رقم الأكسشن: | edsdoj.15c9bcfe2d5945af88a482ec6a0a69e8 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17517176 15246175 |
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| DOI: | 10.1111/jch.14827 |