دورية أكاديمية
Dramatic response to immunochemotherapy followed by salvage surgery in an elderly lung cancer patient
| العنوان: | Dramatic response to immunochemotherapy followed by salvage surgery in an elderly lung cancer patient |
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| المؤلفون: | Yoshio Okano, Michihiro Kunishige, Yoshihiro Kondo, Naoki Kadota, Atsushi Morishita, Keishi Naruse, Hisanori Machida, Nobuo Hatakeyama, Hiroyuki Hino, Tsutomu Shinohara, Shoji Sakiyama, Eiji Takeuchi |
| المصدر: | Thoracic Cancer, Vol 13, Iss 3, Pp 510-513 (2022) |
| بيانات النشر: | Wiley, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | advanced squamous cell carcinoma of the lung, immune checkpoint inhibitor, induction immunochemotherapy, pathological complete response, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Abstract Immune checkpoint inhibitors (ICIs) have caused a paradigm shift in the treatment of lung cancer. Here, we encountered a case of inoperable locally advanced squamous cell carcinoma of the lung that became operable with pembrolizumab‐based immunochemotherapy and achieved a pathological complete response. An 82‐year‐old man suspected of having lung cancer was referred to our hospital. The patient was clinically diagnosed with left upper lobe squamous cell carcinoma cT2aN3M0 c‐stage IIIC. Immunostaining revealed the expression of programmed death‐ligand 1 in 60% of tumor cells. The cancer cells disappeared after two cycles of chemotherapy with carboplatin and nanoparticle albumin‐bound paclitaxel plus pembrolizumab. As the abnormal accumulation of 18F‐fluorodeoxyglucose (FDG) on FDG‐positron emission tomography/computed tomography before chemotherapy almost disappeared after pembrolizumab‐based immunochemotherapy, left upper lobectomy and lymph node dissection were performed. No cancer cells were pathologically detected from the resected tissue. Therefore, ICIs combined with chemotherapy may enable inoperable advanced lung cancer patients to undergo surgery and achieve a complete response. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1759-7714 1759-7706 |
| Relation: | https://doaj.org/toc/1759-7706; https://doaj.org/toc/1759-7714 |
| DOI: | 10.1111/1759-7714.14293 |
| URL الوصول: | https://doaj.org/article/ac15fd10eb6440cba6bddaf53854ae07 |
| رقم الأكسشن: | edsdoj.15fd10eb6440cba6bddaf53854ae07 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17597714 17597706 |
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| DOI: | 10.1111/1759-7714.14293 |