دورية أكاديمية
The Regulation of JNK Signaling Pathways in Cell Death through the Interplay with Mitochondrial SAB and Upstream Post-Translational Effects
| العنوان: | The Regulation of JNK Signaling Pathways in Cell Death through the Interplay with Mitochondrial SAB and Upstream Post-Translational Effects |
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| المؤلفون: | Sanda Win, Tin Aung Than, Neil Kaplowitz |
| المصدر: | International Journal of Molecular Sciences, Vol 19, Iss 11, p 3657 (2018) |
| بيانات النشر: | MDPI AG, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | reactive oxygen species, PTPN6, SRC, DOK4, p38, MKK4, MKK7, p53, DUSP1, SIRT2, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | c-Jun-N-terminal kinase (JNK) activity plays a critical role in modulating cell death, which depends on the level and duration of JNK activation. The kinase cascade from MAPkinase kinase kinase (MAP3K) to MAPkinase kinase (MAP2K) to MAPKinase (MAPK) can be regulated by a number of direct and indirect post-transcriptional modifications, including acetylation, ubiquitination, phosphorylation, and their reversals. Recently, a JNK-mitochondrial SH3-domain binding protein 5 (SH3BP5/SAB)-ROS activation loop has been elucidated, which is required to sustain JNK activity. Importantly, the level of SAB expression in the outer membrane of mitochondria is a major determinant of the set-point for sustained JNK activation. SAB is a docking protein and substrate for JNK, leading to an intramitochondrial signal transduction pathway, which impairs electron transport and promotes reactive oxygen species (ROS) release to sustain the MAPK cascade. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 |
| Relation: | https://www.mdpi.com/1422-0067/19/11/3657; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms19113657 |
| URL الوصول: | https://doaj.org/article/16161e1bfe7045dc8d41827e9846fc61 |
| رقم الأكسشن: | edsdoj.16161e1bfe7045dc8d41827e9846fc61 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 |
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| DOI: | 10.3390/ijms19113657 |