دورية أكاديمية
Propranolol inhibits the proliferation, migration and tube formation of hemangioma cells through HIF-1α dependent mechanisms
| العنوان: | Propranolol inhibits the proliferation, migration and tube formation of hemangioma cells through HIF-1α dependent mechanisms |
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| المؤلفون: | Y.Z. Chen, N. Bai, J.H. Bi, X.W. Liu, G.Q. Xu, L.F. Zhang, X.Q. Li, R. Huo |
| المصدر: | Brazilian Journal of Medical and Biological Research, Vol 50, Iss 12 (2017) |
| بيانات النشر: | Associação Brasileira de Divulgação Científica, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Medicine (General) LCC:Biology (General) |
| مصطلحات موضوعية: | Propranolol, Hemangiomas, Hypoxia inducible factor-1α, Knockdown, Regression, Medicine (General), R5-920, Biology (General), QH301-705.5 |
| الوصف: | The aim of this study was to investigate the mechanism of propranolol on the regression of hemangiomas. Propranolol-treated hemangioma tissues were collected and the expression of hypoxia inducible factor-1α (HIF-1α) was examined. We also established HIF-1α overexpression and knockdown hemangioma cells, and determined the effects of HIF-1α on the hemangioma cells proliferation, apoptosis, migration and tube formation. Significantly increased HIF-1α level was found in the hemangioma tissues compared to that in normal vascular tissues, whereas propranolol treatment decreased the HIF-1α level in hemangioma tissues in a time- and dose-dependent manner. Moreover, propranolol treatment significantly decreased cell proliferation, migration and tube formation as well as promoted cell apoptosis in HIF-1α overexpression and knockdown hemangioma cells. Propranolol suppressed the cells proliferation, migration and tube formation of hemangioma cells through HIF-1α dependent mechanisms. HIF-1α could serve as a novel target in the treatment of hemangiomas. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1414-431X 1414-431x |
| Relation: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017001200601&lng=en&tlng=en; https://doaj.org/toc/1414-431X |
| DOI: | 10.1590/1414-431x20176138 |
| URL الوصول: | https://doaj.org/article/de162a37747c4ace92b9eb0a9157aadb |
| رقم الأكسشن: | edsdoj.162a37747c4ace92b9eb0a9157aadb |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 1414431X 1414431x |
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| DOI: | 10.1590/1414-431x20176138 |