دورية أكاديمية
Determination of the median lethal dose of indoxacarb pesticide in Wistar rat
| العنوان: | Determination of the median lethal dose of indoxacarb pesticide in Wistar rat |
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| المؤلفون: | Archana Raj, N. Suresh Nair, A.R. Nisha, S. Sujith, C. Divya, R. Shankar |
| المصدر: | Journal of Veterinary and Animal Sciences, Vol 54, Iss 2, Pp 510-515 (2023) |
| بيانات النشر: | Director of Academics and Research, Kerala Veterinary and Animal Sciences University, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Animal biochemistry LCC:Science (General) |
| مصطلحات موضوعية: | indoxacarb, oral ld50, wistar rats, acute oral toxicity, hepatotoxicity, Animal biochemistry, QP501-801, Science (General), Q1-390 |
| الوصف: | Indoxacarb is a novel organophosphate substitute and is considered a “lower risk” pesticide in agriculture. However, in humans and animals, indoxacarb exposure had been linked to substantial health problems. This study was carried out to investigate the acute oral toxicity and histopathological changes of indoxacarb in female Wistar albino rats. The acute oral toxicity of indoxacarb was performed as per the OECD guidelines No. 425, (Acute Oral Toxicity - Up-anddown procedure). The LD50 of indoxacarb was estimated using AOT425StatPgm (version: 1.0) statistical program and found to be 1098 mg/kg. Hence the pesticide is categorized as Type II class of pesticide according to the WHO standards. All the animals dosed at 2000 mg/kg died within 12 h exhibiting clinical signs of intermittent episodes of tremors, incoordination, respiratory distress and open-mouth breathing. Histopathological examination of indoxacarb treated rats at 2000mg/ kg degeneration of hepatocytes and necrosis in haematoxylin and eosin staining. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0971-0701 2582-0605 |
| Relation: | https://jvas.in/public_html/upload/article_file/article_file_ry1cje.pdf?t=ry1cje; https://doaj.org/toc/0971-0701; https://doaj.org/toc/2582-0605 |
| DOI: | 10.51966/jvas.2023.54.2.510-515 |
| URL الوصول: | https://doaj.org/article/c16bf6be6ed743a98c300db7c3b508b5 |
| رقم الأكسشن: | edsdoj.16bf6be6ed743a98c300db7c3b508b5 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 09710701 25820605 |
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| DOI: | 10.51966/jvas.2023.54.2.510-515 |