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Incorporating Germanium Oxide into the Glass Phase of Novel Zinc/Magnesium-Based GPCs Designed for Bone Void Filling: Evaluating Their Physical and Mechanical Properties

التفاصيل البيبلوغرافية
العنوان: Incorporating Germanium Oxide into the Glass Phase of Novel Zinc/Magnesium-Based GPCs Designed for Bone Void Filling: Evaluating Their Physical and Mechanical Properties
المؤلفون: Basel A. Khader, Omar Rodriguez, Mark R. Towler
المصدر: Journal of Functional Biomaterials, Vol 9, Iss 3, p 47 (2018)
بيانات النشر: MDPI AG, 2018.
سنة النشر: 2018
المجموعة: LCC:Biotechnology
LCC:Medicine (General)
مصطلحات موضوعية: germanium oxide, bioactive glass, glass polyalkenoate cement, injectability, wettability, Biotechnology, TP248.13-248.65, Medicine (General), R5-920
الوصف: The structural role of Germanium (Ge), when substituting for Zinc (Zn) up to 8 mol % in the 0.48SiO2–0.12CaO–0.36ZnO–0.04MgO glass series, was investigated with respect to both the glass chemistry and also the properties of glass polyalkenoate cements (GPCs) manufactured from them. The Network connectivity (NC) of the glass was calculated to increase from 1.83 to 2.42 with the addition of GeO2 (0–8 mol %). Differential thermal analysis (DTA) results confirmed an increase in the glass transition temperature (Tg) of the glass series with GeO2 content. X-ray photoelectron spectroscopy (XPS) showed an increase in the ratio of bridging oxygens (BO) to non-bridging oxygens (NBO) with the addition of GeO2, supporting the NC and DTA results. 29Si magic angle spinning nuclear magnetic resonance spectroscopy (29Si MAS-NMR) determined a chemical shift from −80.3 to −83.7 ppm as the GeO2 concentration increased. These ionomeric glasses were subsequently used as the basic components in a series of GPCs by mixing them with aqueous polyacrylic acid (PAA). The handling properties of the GPCs resulting were evaluated with respect to the increasing concentration of GeO2 in the glass phase. It was found that the working times of these GPCs increased from 3 to 15 min, while their setting times increased from 4 to 18 min, facilitating the injectability of the Zn/Mg-GPCs through a 16-gauge needle. These Ge-Zn/Mg-GPCs were found to be injectable up to 96% within 12 min. Zn/Mg-GPCs containing GeO2 show promise as injectable cements for use in bone void filling.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2079-4983
Relation: http://www.mdpi.com/2079-4983/9/3/47; https://doaj.org/toc/2079-4983
DOI: 10.3390/jfb9030047
URL الوصول: https://doaj.org/article/16c3daf7b6c540db85442418a94830cb
رقم الأكسشن: edsdoj.16c3daf7b6c540db85442418a94830cb
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20794983
DOI:10.3390/jfb9030047