دورية أكاديمية
Chloroquine to fight COVID-19: A consideration of mechanisms and adverse effects?
| العنوان: | Chloroquine to fight COVID-19: A consideration of mechanisms and adverse effects? |
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| المؤلفون: | Xiping Zhan, Sharon Dowell, Ying Shen, Dexter L. Lee |
| المصدر: | Heliyon, Vol 6, Iss 9, Pp e04900- (2020) |
| بيانات النشر: | Elsevier, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Science (General) LCC:Social sciences (General) |
| مصطلحات موضوعية: | Chloroquine, Hydroxychloroquine, Calcium, HCN, SARS-CoV-2, Cardiology, Science (General), Q1-390, Social sciences (General), H1-99 |
| الوصف: | The COVID-19 outbreak emerged in December 2019 and has rapidly become a global pandemic. A great deal of effort has been made to find effective drugs against this disease. Chloroquine (CQ) and hydroxychloroquine (HCQ) were widely adopted in treating COVID-19, but the results were contradictive. CQ/HCQ have been used to prevent and treat malaria and are efficacious anti-inflammatory agents in rheumatoid arthritis and systemic lupus erythematosus. These drugs have potential broad-spectrum antiviral properties, but the underlying mechanisms are speculative. In this review, we re-evaluated the treatment outcomes and current hypothesis for the working mechanisms of CQ/HCQ as COVID-19 therapy with a special focus on disruption of Ca2+ signaling. In so doing, we attempt to show how the different hypotheses for CQ/HCQ action on coronavirus may interact and reinforce each other. The potential toxicity is also noted due to its action on Ca2+ and hyperpolarization-activated cyclic nucleotide-gated channels in cardiac myocytes and neuronal cells. We propose that intracellular calcium homeostasis is an alternative mechanism for CQ/HCQ pharmacology, which should be considered when evaluating the risks and benefits of therapy in these patients and other perspective applications. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2405-8440 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2405844020317436; https://doaj.org/toc/2405-8440 |
| DOI: | 10.1016/j.heliyon.2020.e04900 |
| URL الوصول: | https://doaj.org/article/16d66b82cbee4b9ab21ba04730b6579d |
| رقم الأكسشن: | edsdoj.16d66b82cbee4b9ab21ba04730b6579d |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24058440 |
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| DOI: | 10.1016/j.heliyon.2020.e04900 |